Release date: 2014-06-25 Super bacteria that are resistant to antibiotics have become a global medical problem. Chinese and British researchers reported on June 19 that they discovered their weaknesses by studying the self-defense mechanisms of such bacteria. Researchers at the University of East Anglia in the United Kingdom and Chinese counterparts at Sichuan University reported in the journal Nature, which they reported on the molecular structure of Gram-negative bacilli, which have impenetrable lipids on their surface. The outer membrane is easily resistant to antibiotics. Using strong X-rays to observe their structure, the researchers found that a class of substances called lipopolysaccharide transporters play a key role in the formation of a defense barrier, which can serve as a carrier to transport the lipopolysaccharide required for the outer membrane. To the surface of the bacteria. The researchers said that the outer membrane of such bacteria is a barrier against antibiotics and drug resistance, and researchers have little understanding of the mechanism of this barrier. In the new study, they not only discovered the carriers and pathways for transporting raw materials for building barriers, but also confirmed that if this path is cut, the barrier cannot form, and such bacteria will die due to difficulties in adapting to changes in the external environment. The researchers said that with this result, it is expected to develop a bactericidal drug targeting lipopolysaccharide transporter in the future. This drug no longer needs to enter the interior of the bacteria, just blocking the formation of the outer membrane of the bacteria, can kill the bacteria, which will help solve the antibiotic problem of super bacteria. Source: Technology Daily One-stop solution, one machine multi-test
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Scientists find super bacteria under the soft rib to block the bacterial outer membrane to kill it