Spinal cord injuries often lead to intractable spasms, but some Swiss scientists have claimed to develop a flexible and stretchable electronic spinal cord that can effectively repair damaged spinal cords and thus cure paralyzed patients.

In a study conducted at the EPFL in Lausanne, Switzerland, the current clinical trials can only cure sputum mice, but the EPFL promises to begin human trials and is expected to launch commercial products soon. At present, there are about 250,000 patients with spinal cord injury in the United States.

Although Neuroprosthetics has been developed specifically for use, it is mostly limited to short-term use because it can cause inflammation and often cause rejection after frequent rubbing with surrounding tissues. EPFL has recently developed a new material called "e-Dura" that is not only bendable and elastic, but can be permanently implanted without causing inflammation or rejection. The experimental mice have been able to regain their mobility after a few weeks of treatment.

The biocompatible implant uses a silicon substrate design that is coated with a gold-plated conductive trace to stretch and bend without damage. (Source: EPFL)

The EPFL e-dura electronic spinal cord has been successfully implanted in completely paralyzed mice, allowing them to walk again normally. (Source: EPFL)

The e-Dura is named after its durability: even if it is severely distorted, it will not cause any damage. (Source: EPFL)

The e-Dura electronic spinal cord can be implanted into the damaged spine and stay indefinitely to restore connectivity lost due to nerve damage. (Source: EPFL)

The electrode at one end of the electron spine is connected to the undamaged nerve in the neck, bypassing the damaged nerve in the sacral spine. (Source: EPFL)

Elasticated spinal implants provide electrical stimulation to the muscles as well as the necessary medical treatment. (Source: EPFL)

"The neuroimplant system is designed to stabilize and treat nervous system damage," said EPFL scientist Stephanie Locur. "Although there are many technologies available, in the long run, these techniques often cause inflammation or even Rejection occurs. Our innovation is to design an implant that is as soft and stretchable as the surrounding tissue, while still integrating the electronic and chemical stimuli, it still has full elasticity."

The system works by utilizing a biocompatible silicon material that allows it to be easily stretched and bent to the same extent as the muscles, but the cracked gold contained in it can be connected to provide stimulation and to monitor the patient's walking. In the specific case, the system can immediately respond and stimulate the right muscles. At the end of the artificial spinal cord is an electrode made of platinum microbeads that can be attached to the neck nerve or directly to the brain. In addition, the microfluidic channels of the artificial spinal cord deliver neurotransmitters, providing more natural stimulation of intact nerves and muscle cells.

Next, scientists plan to conduct more complex and versatile implant clinical trials that can be installed in the human body for many years, and they hope to quickly commercialize their research. Locus is currently working with Professor Gregoire Courtine to further expand the range of applications to treat epilepsy, pain management and Parkinson's disease.

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