Release date: 2016-05-09 The kidney is responsible for filtering the blood, so it is particularly vulnerable to excessive toxins in the blood, which is why some people cause kidney failure after overdose. In this case, how do we make the development of drugs safer? Usually, researchers will experiment in some mammals, but the results are very different from the human body, so everyone can only "speculate" the corresponding "human safe dose." Is there no better way? The good news is that researchers at the University of Michigan have just launched a "kidney-on-a-chip" that can save more lives. The device can more closely mimic the results of the drug flowing through the kidneys in the human bloodstream - each animal is slightly different, but the chip makes it possible for developers to perform a series of more rigorous tests. It looks like a normal slide, but it contains cultured human kidney cells and an infiltrated polyester film sandwiched between the top and bottom. The top layer can be injected with different doses of drug, then guided to the microfluidic channel, traversing the permeable membrane and kidney cells, and finally reaching the bottom. Then, the researchers can check the condition of the cells under the microscope. Details of the study have been published in the recently published journal Biofabrication. Source: cnBeta
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The University of Michigan has developed an "on-chip renal function simulation chip" that precisely reduces the burden on the kidneys