Pharmacological effects

Tian Huang Huang

1. For the cardiovascular system fungus bamboo yellow decoction extract can make isolated frog heart contraction force weakened, heart rate slows down, 1 × 10 \ -2g concentration effect is more intense. There is a direct expansion of the isolated rabbit ear blood vessels, manifested as increased perfusion, especially when blood vessels are in contracture. The mice were injected subcutaneously with a 3.0 g/kg extract of the fungus, bamboo yellow decoction, which had a very significant inhibitory effect on the increased capillary permeability of histamine-induced skin. Intravenous injection of 0.5 g/kg of this extract can reduce blood pressure in anesthetized rabbits, and its mechanism may be related to the influence of cardiac output and the expansion of arterioles and peripheral resistance. 2. Effects on cardiovascular and plasma recalcification time 2×10\-1g concentration can significantly prolong plasma recalcification time. In the hemagglutination test, the drug can prolong the clotting time, which may be related to prolonged recalcification time.

3. Analgesic and anti-inflammatory effects The fungus bamboo yellow decoction extract with subcutaneous injection of 2-3.1g/kg has better analgesic effect on acetic acid-stimulating pain in mice. The crystalline No. III (Bambobacin A) from the extract of bamboo yellow, which was fed at 100 mg/kg, significantly improved the thermal plate method pain threshold in mice, which was superior to indomethacin (indomethacin). Similar to pethidine (10 mg/kg); it can significantly reduce the number of writhing reactions caused by acetic acid, and can also significantly reduce the degree of foot swelling caused by egg white.

4. Other effects The fungus Zhuhuang polysaccharide SB1 and SB2 have a certain effect on hepatitis after preliminary pharmacological tests.

5. Toxic fungus bamboo yellow decoction extract 15g/kg gavage mice, mice within 72h free movement, normal diet, no adverse reactions; male mice intravenous LD50 6.471g/kg.

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