Release date: 2014-12-26

Researchers have developed an imaging-based test to quickly and accurately determine the sensitivity of bacteria to antibiotics. This method can reduce the test time from about 16 hours to 4 hours, it can effectively help doctors treat patients more quickly, and curb drug resistance caused by excessive use and abuse of antibiotics - this situation has been upgraded and become A global health problem.

When bacteria can multiply in the presence of antibiotics, they are considered to be resistant to the drug, but it takes 16-20 hours to detect the growth of this flora. To speed up the process, Jungil Choi and colleagues designed a test called Single Cell Morphology (SCMA) that tracks the growth of individual bacterial cells.

A camera captures the time-lapse imaging of cells on the chip as they change shape in response to an antibiotic, and researchers can analyze the shape patterns in the image to determine cell growth. Importantly, this test takes into account cell swelling and filament formation, which are normal cellular responses, but are often mistaken for cell growth. The researchers tested four standard strains and nearly 200 hospital samples using a wide range of antimicrobial agents, including the notorious methicillin-resistant Staphylococcus aureus (MRSA) and E. coli. Compared to the clinical gold standard, SCMA gives the same precision results within 3-4 hours. According to the authors, they plan to submit the SCMA test to the Ministry of Food and Drug Safety for approval next year.

Source: EurekAlert Chinese

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