Release date: 2017-10-10

A biochip detection method for rapidly determining pathogens of respiratory diseases has recently begun to be applied - as long as the patient's sputum is detected, the type of bacterial infection can be determined in 2 hours, which is 6 to 240 times faster than the conventional method. Due to the saving of time and symptomatic treatment and avoiding delays, this technology of Beijing Boao Jingdian Biotechnology Co., Ltd. is especially valuable for the treatment of respiratory diseases in children and the elderly.

When it comes to diseases that affect human life, people often ignore respiratory diseases. In fact, the respiratory tract is connected to the outside world and is easily infected. Especially the elderly and children, the resistance is low and it is easy to be infected frequently.

According to the World Health Organization's 2013 statistics on the top 10 causes of death in the world, lower respiratory tract infections ranked third. According to incomplete statistics from the China Center for Disease Control and Prevention in 2011, the mortality rate of pneumonia among children under 5 years old in China is 184/100,000 to 1,223/100,000.

One of the reasons for the high mortality rate of respiratory diseases is that it is impossible to find pathogens quickly and accurately, and to treat them in a targeted manner. In traditional diagnosis and treatment, patients need to take blood tests first to infer whether they are viruses or bacterial infections. After the bacterial infection was determined, the doctor considered using antibiotics, but the most distressing problem came: many people did not get better after using some antibiotics, and even more serious, they could only continue to treat with another antibiotic, and bring the patient Unnecessary pain and economic loss.

The reason is that the traditional method cannot quickly and accurately determine the pathogen type. Doctors usually use broad-spectrum antibiotics. If the pathogen is not sensitive to this drug, it needs to be changed. Therefore, at present, most clinical treatments in China are still in the stage of empirical antibiotic application, and there is a large blindness in the use of advanced antibiotics.

To determine the pathogen, the commonly used identification method in the clinic is the bacterial culture method - usually takes about a week to get the results; and the special strain identification time is longer, which will delay the treatment time of patients with severe respiratory infection.

In recent years, with the rapid development of molecular biology, pathogenic diagnosis and molecular biology technology have been closely combined to form a molecular diagnostic technique for pathogens. In view of the problems of difficult cultivation of pathogens, long detection period and low diagnostic rate, Boao Jingdian has introduced a nucleic acid detection system for respiratory pathogens. By detecting the sputum of patients, it is possible to judge the type of bacterial infection in 2 hours. Traditional detection methods are 6 to 240 times faster, completely breaking the limitations of traditional detection. In addition, with its advantages of fastness, accuracy, sensitivity and specificity, it has a prominent role in the diagnosis of pathogenic diseases, providing reliable technical support for the diagnosis, treatment and research of bacterial resistance mechanisms of lower respiratory tract infections.

Accurate early diagnosis of pathogenic bacteria is the key to curing patients. Choosing the best detection method can shorten the course of treatment and save costs. The respiratory pathogen bacterial nucleic acid detection system can solve the problem of not taking medicine seriously, so that we can eat less wrong medicine. The 3-year-old patient clearly had no symptoms of pneumonia after two days of admission, and had symptoms such as difficulty breathing. He could only use a ventilator to maintain his life. The child was seriously ill, the hospital used the highest level of antibiotic treatment, and the condition still did not improve; later, the respiratory pathogen nucleic acid detection chip test was used. After 2 hours, according to the test results, the doctor used the antibiotics against the pathogenic bacteria and the daily cost was greatly reduced. The condition is well controlled. Three days later, the child resumed spontaneous breathing, entered the general ward for observation, and was quickly discharged from hospital.

According to Gao Zhancheng, director of the Department of Respiratory Medicine, Peking University People's Hospital, the nucleic acid detection products for respiratory pathogens have been developed since 2006. After clinical verification, this product can effectively and conveniently detect patients with only one sputum, and can quickly detect 8 common lower respiratory tract pathogens in one hour.

It is understood that the system can be used for the detection of respiratory pathogens, and can also be applied to multiple clinical tests such as detection of pathogenic bacteria in the digestive tract and detection of pathogenic bacteria in wound infections, for rapid diagnosis, precise treatment of infectious diseases and response to major public health emergencies. Provides an effective tool. According to industry insiders, if this technology is widely promoted, it will not only avoid misdiagnosis during the window period, but also accurately identify the cause, target drug delivery, and avoid drug abuse.

Source: Economic Daily

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