Release date: 2017-06-13

Constantly chasing the dream of medical recorder

The medical three-recorder used by Dr. McCoy in the Star Trek series is a magical instrument that scans patients and immediately gives diagnostic results, basic vital signs and health parameters. It is also a lot of doctors in real life. dream. In 2012, Qualcomm announced the launch of the Qualcomm Recorder XPRIZE competition. The five-year competition ended on April 12, 2017. The Final Frontier medical equipment team and the Dynamic Biomarkers team won the championship respectively. See Qualcomm III. Recording X-Prize Grand Prix decided to win and lose, medical three-recorder has become a reality.

If you look closely at the DxtER from the champion Final Frontier Medical Devices, it functions more like a non-invasive medical diagnostic gadget than an all-in-one scanner. It measures heart rate, blood pressure, respiratory rate, body temperature and oxygen saturation. It provides a Mono detection kit, an ECG monitor, and a device like the DxtER Orb that makes it a thermometer and a stethoscope. However, it takes several years for these gadgets to mature and be brought to market. The startup actually plans to use a $2.5 million bonus to conduct clinical trials of up to 500 people.

The runner-up Dynamical Biomarkers Group provided a solution that looked like something between the first aid kit and the tackle box. It offers a variety of blood testing tools and sensors for detecting vital signs and an intelligent zoom lens in the kit. It can be seen that XPRIZE contestants are working hard to implement a simple, immediate diagnostic process (patients can carry them around and can be used anywhere).

How does the portable diagnostic device currently on the market work?

Although the above devices can measure many vital signs and health parameters, the "Star Trek" three-recorder used by Dr. McCoy is still far from reality. However, any portable digital health innovation that makes diagnosis faster, more accurate, and less expensive is critical to achieving immediate patient detection. In the 21st century, we still need to spend time and energy to detect basic vital signs, which is really bad. This process should be step 0. When the patient meets the caregiver, any required data should be accurately obtained. This is a concept that portable diagnostic devices are designed to support and further develop.

This article will provide a simple analysis of the performance of portable diagnostic equipment on the market today for those who want to further develop existing innovations. How good are they for detecting health parameters? Have you obtained FDA approval? How accurate is the test? How user-friendly are they? Can I communicate with my smartphone? The latter is a key reason for including devices as digital health devices. Regardless of the outcome of measuring health parameters, communicating with a smartphone should be an important part of the system's impact.

Digital stethoscope

From asthma and pneumonia to colds, doctors have relied on stethoscopes to diagnose common diseases. Modern stethoscopes have become a symbol of doctors, and digital stethoscopes have taken older equipment to new heights to meet the needs of the 21st century.

a) Clinicloud

This is one of the best digital health devices on the market today. It is small, simple to operate, and portable and intelligent. It allows patients and doctors to detect heart rate, as well as record heart and lung sounds and automatically save them to the APP. Because it combines next-generation infrared technology with Bluetooth connectivity, you can remotely transmit test results to clinicians for later comparison. Clinicloud also added a thermometer to its device to read the temperature without touching the skin.

b) Eko Core

The Eko Core digital stethoscope has many similarities to the Clinicloud. It's also small and portable, and it fits in the pockets of busy doctors. It is also very simple to use and provides intelligent detection of the heart, lungs and other sounds. When using Eko Core, healthcare professionals can also use their mobile devices to save, process and share sound data. The difference with Clinicloud is that Eko Core can also work in analog mode, which means it can be used like a traditional stethoscope. This may sound good, perhaps helping to convince health care workers who are not willing to use digital health innovations to try out new technologies.

Single channel electrocardiogram

a) WIWE

Wiwe is a smart sensor that uses a unique intelligent algorithm to evaluate the waveform properties of an electrocardiogram to calculate the risk of stroke and cardiac arrest associated with fibrosis. It not only provides accurate data on ECG, blood oxygen levels or different physical activities, but also uses the pedometer function to help reduce the risk associated with heart disease. Based on the connectivity of smart gadgets, if anything, such as a cardiac arrest, occurs, not only the user itself, but his chosen partner (lover and relatives) can also immediately understand.

b) Kardia of AliveCor

Kardia is an FDA-approved medical grade ECG recorder. It's only a little thicker than a credit card and fits perfectly into your wallet or pocket. The default option for a heart monitor is to record for 30 seconds and perform an appropriate analysis after heart rate is detected. This means that it will immediately tell you if the ECG is normal, whether there may be atrial fibrillation, or whether you may experience some “unclassified” risks such as premature atrial contraction (PAC) or premature ventricular contraction (PVC). .

Multi-channel ECG - ECG Dongle

The ECG monitor described above is a single-lead ECG, commonly referred to as a heart rhythm map; and a multi-channel ECG (usually a 12-lead) can record information from different perspectives of the heart and provide a more comprehensive picture of ECG activity. Although both types of ECG monitoring are feasible, there is only one intelligent multi-channel ECG device on the market: ECG Dongle developed by the Russian company Nordavind. It enters the market in two versions: one for regular users and one for medical professionals. This is actually a small tool for USB flash drives. The version for normal users passes through 6 standard channels (I, II, III, aVR, aVL, AVF), while the medical staff uses 12 standard channels to calculate User's heart data. To be sufficient to detect various (100%) arrhythmia, the device requires four or ten electrodes at the same time. Although ECG Dongle is quite good, it has not received any approval from the FDA (or any similar medical regulatory agency).

Multi-function sensor

a) Viatom Checkme Pro

This is probably the closest device to a medical recorder. It's really multifaceted: as a health tracker (like a wearable sensor), you can record your electrocardiogram (cardiac electrophysiology), measure your oxygen saturation, record your daily steps, and use As a thermometer, blood pressure monitor, sleep monitor and reminder device. It is a truly functionally integrated device. At the same time, it is also portable, very lightweight, and can transfer data wirelessly and handheldly. In addition, it is FDA-approved and has amazing battery life. It can be used in both home and clinical settings, especially for professional healthcare professionals. You can even use it as a 24-hour ECG Holter monitor.

b) Viatom O2 sleep monitor

Although the O2 sleep monitor is first positioned as a sleep tracking device, it is also capable of detecting many vital signs and health parameters. It monitors your blood oxygen and heart rate levels as well as your movements. When your blood oxygen level drops too low (eg below 90%), a small vibration function can help solve the oxygen shortage. Basically, such vibrations will allow you to change your body position while you sleep, which is a very useful feature for people who have difficulty breathing and snoring.

Thermometer - Wishbone

Obviously, the reason why the device got such a name is because it looks like a wishing bone that people use to pray for good luck, which represents people's best wishes for children in the world. Although the Wishbone Smart Thermometer was developed to take the temperature of a child, you can use it for a few seconds to measure the temperature of your child's food or the temperature outside. It is non-invasive, reliable and versatile, but it has not received FDA approval. Developers who are father and baby goods store owners realize that a small thermometer that can measure and monitor temperature using a smartphone is necessary, and it is undeniable that this is a good idea.

Blood Pressure - Withings Blood Pressure Monitor

There are many good blood pressure monitoring devices on the market, but there are very few digital devices that can be connected to smart devices. The Withings Blood Pressure Monitor is an exception: easy to use, stylish, FDA approved, and wireless and digital. Just put it on your wrist, turn on the device, and the Health Mate APP will start automatically. According to its simple tips, you are ready to measure your blood pressure. The app will give you immediate feedback based on international hypertension recommendations. Over time, it helps you better understand your heart health, and the Health Mate APP can store all your blood pressure readings. In addition, it creates an easy-to-understand chart that helps reflect blood pressure.

Portable medical device matrix

summary

As digital health progresses, more new devices will emerge; at the same time, we will need the help of regulatory agencies like the FDA to filter out inferior products and leave those that are truly reliable.

Reference material

Rating Portable Diagnostic Devices That Make Patients the Point-of-Care

Source: Flint Creation (WeChat: firestone-link)

ELISA Analyzer

Processing high-throughput samples, intelligent reuse for large-capacity publishing, work surface: 200cm, 8 sample injection needles, 12 temperature-controlled incubation positions, 12 room temperature incubation positions, 32 plate storage positions, Sunrise microplate reader, HydroFlex plate washer, up to 512 specimens, sequential loading of samples, reagents, microplates Parallel loading of up to 6 plates for fast dispensing.

The automatic enzyme immunoassay analyzer is based on the principle that the enzyme and the substrate can produce a color reaction, the absorption lines of different substances have different characteristics, and strictly abide by the Lambert-Beer law, quantitative and qualitative analysis of substances. instrument. The method of analyzing the content of various enzymes such as antigen or antibody generally mainly adopts colorimetric method. In practice, spectrophotometry is the basic working principle of an automatic enzyme immunoassay analyzer. The light emitted by the light source lamp becomes a beam of monochromatic light after passing through a filter or a monochromator. The monochromatic light beam passes through the sample to be tested in the microtiter plate, and part of the monochromatic light beam is absorbed by the sample and reaches the photodetector. The intensity of the light signal projected on it is converted into the magnitude of the electrical signal by the photodetector. This electrical signal is processed by pre-amplification, logarithmic amplification, analog-to-digital conversion, etc., and then sent to the microprocessor for data processing and calculation, and the test results are output by the display and printer. The microprocessor completes the movement in the X and Y directions of the mechanical drive through the control circuit.
The automatic enzyme immunoassay analyzer adds the sample to the microwells of the pre-coated antigen or antibody microtiter plate, washes after the reaction, removes the unseparated ligand, then adds the enzyme isolate, after incubation, washes again , remove the unseparated compound, and then add the enzyme substrate, after the reaction, the colored final product is formed, and the stop solution is added to stop the reaction. The absorbance of each microwell of the microtiter plate is read by the wavelength that has been set by the spectrophotometer. The concentration value of the analyte in the sample is calculated by the absorbance value of the sample and the standard curve, so that the quantitative result can be obtained, or the absorbance of the sample is compared with that of the standard product, so that the positive or negative qualitative result can be obtained.

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