Human genomic DNA loop HD 4D map is drawn October 09, 2017 Source: People w The latest issue of Cell, published a cover article of the joint research team at Baylor College of Medicine, Rice University, Stanford University, and the Broad Institute: they mapped HD to 4D in the nucleus of the genome. Map. The new study provides a dynamic tracking of the complete folding of the entire genome at different times, which will help scientists to study genetic diseases such as cancer from a new perspective. For decades, scientists have speculated that after human cells are stimulated, the DNA (deoxyribonucleic acid) elements in their nucleus will quickly find distant counterparts, forming different rings along the chromosomes, by spatially re- In the layout, cells can alter the activity of genes and thereby regulate cell function. However, DNA loops have long been a major blind spot in modern biology. Although it is known that DNA can form loops in cells, determining the specific location of these loop structures has been an impossible task. Until 2014, the above-mentioned joint research team made a complete change. They succeeded in mapping an unprecedented detailed map of how the human genome folds into a loop, and demonstrated that humans and other mammals, such as mice, are not only highly similar in one-dimensional genomic sequences, but also have similar three-dimensional genome folding. However, these maps can only reflect a ring structure in a static state, and it is impossible to observe the dynamic process of the ring structure. In the latest study, the joint team produced the 4D HD video of the DNA loop in the human genome for the first time and clarified the unique mechanism associated with the looping position. By destroying the cyclic protein complex, Cohesin, in almost all cyclic structures, they found an extrusion mechanism that controls the DNA loop: adhesion proteins are like strap adjustment buckles for backpacks, through delivery sheets. Side straps, adjustable buckles can make the straps form a ring to adjust the length of the straps, and the adhesion protein can regulate the formation of DNA loops like the adjustment buckle. By carefully observing the video map, the researchers also found another blocking mechanism that is not related to adhesion proteins, and the extrusion mechanism allows DNA to form a circular structure along the same chromosome through two elements. The cloning mechanism can Let the elements on different chromosomes combine into a ring structure in the form of large atomic groups. Researchers say that these mechanisms can regulate the formation and disintegration of DNA loops, thereby further understanding the cellular functions based on these folded structures. ( Pressure Compensation Emitter Automatic Assembly Machine And Products
Shandong Chunyu Water-saving Irrigation Equipment Co., Ltd., founded in 2011, is located in Laiwu High-tech Zone, Jinan City. It is a high-tech enterprise focusing on innovative and efficient emitter mold manufacturing and emitter product research and development and production. After nearly ten years of innovation and development, it is the invisible champion enterprise in Shandong Province, and now it is in a leading position in this field in China.
Spring rain people-oriented, build talent highland. At present, the company has 16 high, fine and advanced technical personnel, and cooperates with a number of scientific research institutes, forming a mold design, emitter testing, flow testing and other professional technical personnel team. In recent years, it has obtained 3 invention patents, 33 utility model patents and 3 patent awards. In 2019, it was identified as an intellectual property advantage enterprise in Jinan. It has undertaken 4 provincial science and technology innovation projects and won 2 second prizes of Shandong Science and Technology Progress Award. The company has built Jinan drip emitter mold engineering technology research center, the company has a slow wire cutting, CNC machining center, precision EDM machine, 3D projection measuring instrument, CNC engraving, laser engraving and other advanced processing equipment. Mature technology and rich experience support the excellent quality of Chunyu. Spring Rain pays attention to every link of production, implements 8S management, strictly controls the quality of products at the beginning, the middle and the end, and forms the seamless link of production management. The company has independently researched and developed flat emitter molds with full hot runner, cylindrical emitter molds with full hot runner and other products. With excellent quality, competitive price and good after-sales service, the company is well known at home and abroad, and has been sold well in Egypt, India, Iran, Turkey, Saudi Arabia, the United States and other countries.
With the vision of "building a global professional emitter mold supplier" and the mission of "providing solutions for efficient and innovative production of global water-saving irrigation enterprises", the company takes "scientific and technological innovation to scale new heights; Keep improving, the pursuit of excellence; Honesty and trustworthiness, win-win cooperation "for the values of the enterprise. For the construction of water - saving and resource-saving society to make a positive contribution.
Hose Reel Irrigation Machine,Automatic Emitter Assembly Machine,Agriculture Irrigation Equipment,Automatic Irrigation Equipment Shandong Spring Rain Water Saving Irrigation Equipment Co.,Ltd. , https://www.drippermould.com
Human genomic DNA loop HD 4D map is drawn