In recent days, Associate Professor Han Chunyu’s report on the major original achievements of Nature Biotech has captured the headlines of many media and praised everyone. Many researchers believe that the NgAgo-gDNA technology reported by Han Chunyu is more suitable for human genome editing and will likely surpass the CRISPR-Cas9 technology. For professional interest, the author searched Han Chunyu's patent and found some problems, which were proposed for researcher's reference.

Han Chunyu and John van der Oost both published papers in nature

Let's take a look at Han Chunyu's entire process from producing research ideas to "Nature Biotech".

Han Chunyu's research on NgAgo was inspired by the article "DNA-guided DNA interference by a paokaryotic Argonaute" published by John van der Oost of Wageningen University (Netherlands) in the journal Nature. The article introduces TtAgo. (Thermus thermophilus Argonaute) can cut DNA using DNA as a template.

Inspired by van der Oost, the Han Chunyu team started experimenting in the first half of 2014. Two months later, NgAgo was able to do genetic editing tools. After the initial results of the experiment, Han Chunyu submitted a contribution to the journal Science. During the review of Science, Han Chunyu's research team continued to improve the experimental results. In the fall of 2014, Zhejiang University Shen Xiao also began to participate in this work. After a half-year review by Science magazine, Han Chunyu’s submission was eventually rejected. It is estimated that this time is about October. After supplementing the experimental content, the experimental paper was changed to "Nature Biotechnology" on June 3, 2015. After 9 months, the article was accepted in February 2016, and was published online on May 2, 2016. From the beginning of the study, to the publication of the paper, about two years before and after.

Also, let me introduce John van der Oost.

John van der Oost is currently working at Wageningen University in the Netherlands. He began researching the CRISPR field in 2005. He is a research member of the early CRISPR, working with both Zhang Feng and Jennifer Doudna. The latest public patent shows John van der Oost also at Caribou Biosciences. Among the inventors' list, the company was founded by Jennifer Doudna.

John van der Oost's article "DNA-guided DNAinterference by a paokaryotic Argonaute", submitted on July 30, 2013, was published on February 16, 2014.

Both Han Chunyu and John van der Oost applied for a patent.

First look at John van der Oost's patents filed around TtAgo:

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