Release date: 2016-09-07 Chinese researchers published a paper on the online edition of the journal Nature Methodology on September 5th that they developed a new technology to efficiently control the CRISPR-Cas9 gene editing system to achieve targeted intervention in cancer cells. In recent years, the rapidly developing CRISPR-Cas9 system has strong genetic editing and regulation capabilities. Through the precise "guide" of sgRNA and the implementation of targeted gene function by cas9 nuclease, the two cooperate to achieve editing and regulation capabilities. This system has been widely used in many fields such as life sciences and medicine. However, there are still many aspects to be perfected in the application process, such as avoiding problems such as “use out of control†and “over-editingâ€. Researchers at Shenzhen Second People's Hospital realized the control of the CRISPR-Cas9 system by complementing the nucleic acid aptamer RNA stem sequence and the sgRNA in the CRISPR-Cas9 system to recognize the sequence of the target gene, forming a set of precise control New technologies for multiple functions such as gene activation, inhibition and cleavage. The traditional method mainly uses external "power" to eliminate cancer cells, but it often damages normal cells and causes great side effects. For cancers with genetic mutations that cause abnormal cell signaling, researchers use new techniques to control the direction of signal flow in cancer cells, effectively intervene in multiple "malignant" behaviors of cancer cells, and initiate their own death programs. Researchers have validated the effectiveness of the new tool with multiple types of cancer cells, including bladder cancer. Liu Yuchen, the first author of the paper and the Second People's Hospital of Shenzhen, told the Xinhua News Agency: "This is not easy or impossible to achieve in the past, and because normal cells do not have cancer-specific molecules, they are basically not influences." The author of the paper, Huang Weiren of the Second People's Hospital of Shenzhen, said: "The research team is testing the effectiveness and biosafety of some in vivo gene delivery systems, such as engineered E. coli, oncolytic viruses, immune cells, nanoparticles, and so on. If the future is successful, it will be able to further enhance the anti-cancer effect of this tool, and it can also be extended to many fields, and precise treatment programs for various diseases including cancer and diabetes are also expected to be changed." Source: Xinhuanet Lishida Red Vinegar,which is brewed from high quality rice and other ingredients,is usually used for pickling,making salads and cooking.Also,it's great for seasoning the seafoods such as crabs and clams.You can add directly into noodles for fresh taste too.It's available for bulk wholesale and warm welcome friends who owns supermarkets and restaurants for cooperation. Red Vinaigrette,Red Vinegar in Cantonese,Red Vinegar Dipping Sauce KAIPING CITY LISHIDA FLAVOURING&FOOD CO.,LTD , https://www.lishidafood.com
China has developed a new technology for gene editing system control: achieving targeted intervention of cancer cells