According to a medical paper published by the UK's "Nature and Communications" magazine, scientists have discovered a non-invasive method to detect myocardial cell death. By measuring circulating free DNA released by dying cardiomyocytes, it is possible to diagnose and monitor myocardial diseases associated with cell death, such as myocardial infarction (heart disease) and sepsis, with high sensitivity and specificity.

The original power of human blood circulation comes from the contraction and relaxation of the heart, but various pathogenic factors, such as infection, elemental deficiency, poisoning, and severe and long-lasting ischemia, can directly cause the death of the myocardial cells, which in turn causes the dysfunction of the myocardium. , eventually leading to morbidity. Among them, myocardial infarction is myocardial necrosis caused by acute and continuous ischemia and hypoxia of coronary arteries. Surveys show that about 1.5 million people in the United States have myocardial infarction every year, and Asian countries have also shown a significant upward trend in recent years; sepsis is a cause of illness. Infection of bacteria or conditional bacteria into the blood circulation, growth, reproduction, and production of toxins results in an acute systemic infection that causes pericarditis or endocarditis.

This time, a team of scientists from the Hadassah School of Medicine at Hebrew University in Israel discovered a methylation marker in the DNA of human cardiac muscle cells and developed a method for detecting the marker in blood.

Studies have confirmed that this method has high sensitivity and specificity and can diagnose patients with heart disease. The effect is similar to the detection of troponin levels in the blood, which is the gold standard for clinical detection of heart tissue damage. In the plasma of patients with sepsis, the level of cardiomyocyte-specific free DNA was markedly elevated, indicating the large-scale death of cardiomyocytes in patients. Compared with troponin, this newly discovered marker is more indicative of short-term mortality due to sepsis.

The researchers said that although the link between circulating free DNA and cell death needs to be fully demonstrated, scientists believe that the above new methods may complement known known biomarkers of heart damage and are expected to help clinicians distinguish between myocardial cells. Death and reversible cell damage. (Reporter Zhang Mengran)

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