Release date: 2015-07-23

Recently, the "paper machine", a disease detection platform researched by scientists at Harvard University, has drawn a lot of attention from the industry. Through the platform's special instruments, cancer, infectious diseases and some genetic diseases can be detected at a cost of no more than $2. “paper machine” includes concentrated sample preparation, DNA analysis and disease detection processes, and the entire diagnostic process costs less than $2, making it the cheapest of all technologies.

The results were published in the latest issue of Analytical Chemistry, and the following figure is a simple flow chart of product operation.

First, add a microfluidic sample to the "paper machine";

Next, a buffer (Buffer) is added along the pre-formed jet path;

Then, adding the mixed LAMP reagent;

Finally, a dye with a green excitation wavelength (SYBR Green I) bound to all dsDNA double helix minor groove regions was observed under UV illumination.

The main steps of the paper machine

Scientists say the technology combines the advantages of microfluidics and multichannels, and is like a "paper machine." Once the product goes on the market, more third-party diagnostic laboratories will be introduced to consumers. Avoid going to the hospital for expensive diagnostic tests recommended by doctors. They believe that under certain conditions, this paper machine has the potential to replace diagnostic reagents.

This product not only has an advantage over traditional diagnosis in terms of price, but also is more efficient in diagnosis. It is also an innovation. In the case of traditional red blood cells, the device can detect 5 E. coli cells (E. Coli cells).

Scientists also said that blood diagnostic results can be read on a smartphone or read through an ultraviolet device. So far, researchers are also trying to develop more simplified and more practical diagnostic processes based on "paper machine".

Core technology interpretation: LAMP technology

LAMP can perform nucleic acid amplification in a short time (usually within one hour) under isothermal (60-65 ° C) conditions, which is a "simple, rapid, accurate, low-cost" gene amplification method. The full name is Loop-mediated isothermal amplification method (LAMP).

As a molecular biology detection technology, it has the characteristics of high specificity, high sensitivity, simplicity, convenience and low cost. It has been widely used in the diagnosis of clinical diseases, qualitative and quantitative detection of epidemic bacteria or viruses, and sex identification of animal embryos. And the field of gene chip development.

Source: CFDA

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