The brain is so eternal

Release date: 2017-01-13

Whenever people want to learn something new, they not only need to acquire new memories, but also need to stabilize in a process called memory consolidation. Brain waves are thought to play an important role in this process, but the mechanism is still unclear. A recent study published in the journal Neuron shows that a brainwave that is important for the consolidation of memory is controlled by synaptic inhibition.

The brain waves of so-called sharp waves (SWRs) emanating from the hippocampus of the brain are related to stable memory, which helps the brain to immediately replay what has been learned or experienced. Peter Jonas, a professor at the Austrian Institute of Technology, and Jozsef Csicsvari, found a mechanism for this neurological shock in mice.

Csicsvari said, "SWRs play an important role in the brain, but the mechanism of its production is not clear. The technical limitations in the experiment may be part of the reason. We hope to obtain the first high-resolution prominent current record when SWRs appear in active mice. And determine whether the time adjustment of sputum from the stimulus is suppressed by the junction (synapse) in the brain cells."

It is reported that the researchers monitored the brain signals of 17 fully awake mice, which were then groomed and groomed in the same way as other normal mice. It was found that the frequency of excitatory stimulation and inhibitory events in the synapses of the mice increased in the presence of SWRs.

However, when SWRs are produced, the number of synaptic inhibition exceeds the stimulus. In addition, the magnitude of the suppression event is also significantly positively correlated with the amplitude of the SWRs. These suggestive suppression events are drivers of neurological oscillations. In the end, the researchers believe that a nerve cell called PV+ interneurons is important for the production of SWRs. Previous studies have shown that light-stimulated PV+ interneurons can exhibit narrow peak bandwidths, as well as a higher rate of excitation, and exhibit a short and consistent cycle of inhibition for neighboring nerve cells.

Later, the researchers proposed a model containing two specific regions of the hippocampus (CA1 and CA3). The model shows that the vibrational stimulation of CA3 and the phase inhibition of CA1 work together to generate SWRs.

Source: Science Network

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