Shandong University Research Team Confirms New Targets for Treatment of Acute Kidney Injury March 16, 2018 Source: Xinhuanet The research team of Shandong University recently published the latest research results in internationally renowned medical journals, confirming the role of Gpr97 gene in nephropathy for the first time. Experts believe that this provides a new genetic target for the future treatment of acute kidney injury. This research team is led by Yi Fan, a professor at the Basic Medical College of Shandong University. The team's paper entitled "Gpr97 aggravates acute kidney injury by regulating Sema3A signaling pathways" has been published online in the Journal of the American College of Nephrology. In the mouse experiment, the research team found that knocking out the Gpr97 gene can significantly reduce the levels of serum creatinine and urea nitrogen in acute kidney injury, improve the degree of tubular damage, and reduce the infiltration of inflammatory cells, thus affecting acute kidney injury. To protection. The Gpr97 gene belongs to the G protein coupled receptor family. The latter consists of more than 1000 members and is the largest membrane protein family with many physiological functions such as intracellular and extracellular signal transduction, gene transcription, and cell recognition. Currently, more than 30% of clinical gene drug targets are located on G-protein coupled receptors. According to the research team, acute kidney injury is a serious clinical complication with high morbidity and mortality, and is also a major cause of end-stage renal disease. Academic research is gradually revealing the pathological process and pathogenesis of acute kidney injury, but there is still no effective clinical treatment. Finding drug targets for acute kidney injury will help provide new clinical treatment strategies. (Reporter Xiao Haichuan) YT-H706 YT-H706 Shenzhen Sunshine Technology Co.,Ltd , https://www.yatwin.com
Shandong University Research Team Confirms New Targets for Treatment of Acute Kidney Injury