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Researchers at Drexel University and Georgia Institute of Technology found that Rad52 protein is the key to DNA repair. The latest research published in the journal Molecular Cell, in which the researchers explained the important functions of the homologous recombination of the Rad52 protein, a finding that helps identify new targets for cancer treatment.
Radiotherapy and chemotherapy can cause DNA double-strand breaks. The biggest damage is DNA damage. Homologous recombination plays a crucial role in DNA repair. This process involves the exchange of genetic information between two DNA molecules. These genetic mutations can disrupt a genome, for example, breast cancer and ovarian cancer caused by BRCA2 mutations.
In this study, researchers at Drexel University School of Medicine specialize in proteins and mechanisms that promote DNA repair.
The researchers said: "We found evidence that RNA can be used as a donor template to repair DNA , while Rad52 protein is involved in this process, but we don't know how this protein is involved." In this study The team found that the important role of the Rad52 protein is to promote "anti-strand exchange" between double-stranded DNA and RNA, which means that the protein 's ability to homologize DNA and RNA molecules allows RNA to be used as DNA. Repaired template.
In this way, the ability of Rad52 is unique in eukaryotes, and similar proteins have no such ability.
Next, the researchers explored the role of Rad52 protein in human cells, as DNA fragmentation plays a crucial role in many human degenerative diseases, including cancer. The results of this experiment opened a new path for the treatment of diseases such as cancer.
Scientists have found the "key" of damaged DNA repair, and new anti-cancer methods are expected to come out!