Nankai University discovers new targets for anti-Ai drugs December 02, 2015 Source: Xinhuanet Humans have yet to find a cure for AIDS, and the variability of the HIV virus has made vaccine development difficult. The main principle of various antiviral drugs is to inhibit the replication of HIV virus in infected people. The research team led by Wei Min, a professor of medical science at Nankai University, who has long been committed to HIV research, accidentally discovered that the CCDC8 protein on the human cell membrane has a strong inhibitory activity against HIV virus. Under normal circumstances, after the human body is infected with HIV, the virus will invade the inside of the human body and replicate it, and then release it to the outside of the cell. The process is that, under the "guidance" of the viral genome, the host cell synthesizes a structural protein called "Gag" in the cytoplasm. This protein is the main "raw material" that constitutes the backbone of the HIV virus. Gag protein will aggregate in a large amount on the cell membrane to form a multimer and bulge out to the outside of the cell, that is, "germination". Subsequently, the virus "semi-finished product" wraps a viral genome out of the host cell, eventually forming a complete virus particle. The researchers found that when the Gag protein met with CCDC8 on the cell membrane, its "assembly" process was inhibited. CCDC8 induces Gag endocytosis, polyubiquitination and degradation by combining other proteins, such as the cytoskeletal protein Obsl1 and the E3 ubiquitin ligase Cul7. Under the action of CCDC8, the Gag protein, which constitutes the skeleton of the HIV virus, no longer "buds" outward, but is "endoculated" by the cells and is then decomposed. The replication of the HIV virus is effectively suppressed, and the patient's condition is further controlled. "CCDC8 is present on the normal human cell membrane, but the amount is relatively small, it is difficult to inhibit the replication of HIV virus. After the expression of CCDC8 is increased by the exogenous vector expression technology, the anti-HIV activity of the experimental cells is significantly improved. We have reason I believe that CCDC8 can be a new anti-AIDS drug target." Kn95 3D Mask,Kn95 Face Mask,Kn95 Filters Mask,Kn95 Cup Face Mask Jiangmen anjian biotechnology co. LTD , https://www.jmanjianmask.com
Nankai University discovers new targets for anti-Ai drugs