Gene defects can cause hearing "under-power" August 31, 2018 Source: Science and Technology Daily On the 30th, the reporter learned from Zhejiang University that in a study led by Professor Guan Minxin and Chen Yu, a professor at the Institute of Genetics of Zhejiang University, the team researchers used the gene editing technology to obtain the defect of the mitochondrial tRNA post-transcriptional modification gene mtu1 for the first time. The zebrafish model clarifies the molecular pathogenesis of the "culprit" mtu1 of deafness with a comprehensive research perspective. The research results were published online in the internationally authoritative academic journal "Nucleic Acid Research". In this study, the team of Guan Minxin team first constructed the zebrafish model of mtu1 knockout, and explored the pathogenesis mechanism from multiple levels to determine the pathogenic mechanism of mtu1 leading to hereditary deafness, which is the energy required for hearing. The destruction of the power plant. When the mtu1 gene is mutated, there are three kinds of tRNAs that cannot accurately synthesize the protein "machine" of mitochondria-producing energy. The "machine" function is impaired and the power supply of the mitochondria "power plant" is insufficient. Inner ear hair cells are the most important thing in the perception of sound in living organisms. As a highly energy-consuming cell, it needs a large amount of mitochondria to supply energy during life-sustaining activities and functions. When the mtu1 gene affects mitochondrial function, this "power shortage" causes the auditory dysfunction of the organism. This study provides a new scientific basis and treatment for the prevention and treatment of hereditary deafness. (Reporter Jiang Yan) Vitamins are a type of trace organic substances that humans and animals must obtain from food in order to maintain normal physiological functions. In terms of physiological functions, vitamins are neither a raw material for tissues nor a substance for supplying energy, but they are an indispensable substance for the body. It has many types and different chemical structures. Most of them are the components of the coenzyme (or prosthetic group) of certain enzymes. They are the indispensable compounds for maintaining the normal growth (growth, health, reproduction and production function) of the body. It plays a catalytic role in the body to promote the synthesis and degradation of major nutrients (proteins, fats, carbohydrates, etc.), thereby controlling metabolism. Vitamins are essentially low-molecular organic compounds. They cannot be synthesized in the body, or the amount synthesized is difficult to meet the needs of the body, so they must be supplied from the outside. The daily requirement of vitamins is very small (usually measured in milligrams or micrograms). They are neither a raw material for body tissues nor a substance for energy supply in the body. However, they do not regulate material metabolism, promote growth and development, and maintain physiological functions. Vitamin K2 MK-7, Vitamin C, Vitamin E, Vitamin K2, Vitamin H, Vitamin D3 Xi'an Gawen Biotechnology Co., Ltd , https://www.ahualyn-bio.com
Gene defects can cause hearing "under-power"