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In the past 10 years, the development of anti-tumor drug preparations has made oral administration an important route of medication, but it also highlights the problem of medication compliance. After all, drugs can only function if they enter the body. Contrary to expectations, a significant proportion of cancer patients did not take medication as directed.
Professor Joly said: "The initial purpose of the study was to assess the relationship between cognitive function and oral medication adherence in order to judge the characteristics of patients who did not follow the doctor's advice. The study included patients who started a new oral anti-tumor treatment, among which More than half of the ages >70 years. Before starting treatment, patients were given a standardized set of neuropsychological tests, including autonomy, depression and anxiety assessment, and collected sociodemographic information. Patient self-assessment was assessed through self-assessment questionnaires and observations. ."
After analysis, it is concluded that working memory dysfunction (more common in elderly patients) and depression may be predictors of poor compliance. Prior to the initiation of oral anti-tumor therapy, attention to cognitive function was associated with patient characteristics that were difficult to self-administer medications, and understanding these helps to develop appropriate clinical decisions, especially for older patients.
Given that patient compliance plays an important role in anti-cancer therapy, the 2016 ESMO Conference set up the Patient Advocacy Track feature. The use of oral medications that are not prescribed may have an impact on efficacy and even survival, and it also costs expensive for patients and health care systems.
For deliberate adherence, Dr. Bettina Ryll, Chairman of ESMO's Patient Advocacy Working Group, said: "I feel that the concept of current compliance is too narrow. For example, doctors expect patients to take medications according to their will, and poor compliance is considered a defying medical advice. The form of deliberate disobedience, that is, taking the medicine as required, reflects the patient's subjective will, which is different from what the doctor or other stakeholders think. Therefore, adherence is imposed on them instead of the patient's choice. It is better to understand the underlying causes of such non-compliance and then resolve them."
Dr. Ryll also believes that in order to improve the outcome of patients with poor adherence to cancer therapy, oncologists need to understand the corresponding drivers and patient characteristics.
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Expert: cognitive dysfunction or the main factors affecting medication
[China Pharmaceutical Network Health and Wellness] At the 2016 ESMO Annual Meeting, Professor Florence Joly and Dr. Melanie Dos Santos from Centre Francois Baclesse in France conducted a study on oral anticancer drugs ("Impact of cognitive functions on oral" Anticancer therapies adherence"). The findings suggest that cognitive dysfunction may be a major factor in underdosing and neglecting medications, which is more common in older patients.
(Expert: cognitive dysfunction or the main factors affecting medication. Source: Baidu Pictures)