Release date: 2016-03-17

Recently, researchers at the University of Sheffield in the UK have developed a new method that stops stem cells and embryos from developing for a few days and then causes them to resume development. What impact will this have on regenerative medicine?

Researchers have created a mucus in the lab that puts human stem cells and embryonic stem cells into sleep. When immersed in this substance, the cells enter a stagnant state during which they cease to develop, and once the mucus is removed, they begin to divide again. This new substance can change the way stem cells are stored and transported, and may play an important role in "how to prepare stem cells for regenerative medicine."

Steven Armes, from the University of Sheffield, UK, knows that mice, rats, kangaroos and other mammals can make a mucus that blocks embryo development before reaching the best birth conditions. He and his colleagues want to know: Can they make a substance that can do the same for human pluripotent stem cells?

Now, in a study published in ACS Central Science, the team proposed a three-dimensional, hydroxyl-rich gel that blocks stem cell development for at least 14 days. It also stagnates the development of human embryos for up to eight days. Armes was particularly surprised that the cells entered a stagnation period only by being submerged in the gel, which did not interact with the cells. We don't need to add any complicated biochemicals. "

Once the cells are buried in the gel, what happens at the molecular level that triggers cell stagnation? It is not clear at the moment. Armes pointed out: "We know that they change the composition of the nuclear membrane." When embedded in a gel, the cells produce a protein called a nuclear envelope statin, a known cell-stagnating molecule. Mark. This change in nuclear structure was previously thought to be related to the ability of a cell to mechanically perceive the environment. Therefore, manipulating the physical environment of the cell, rather than its biochemical pathway, may be sufficient to delay cell development.

This new gel provides flexibility for scientists studying developmental and pluripotent, and it also provides a good alternative to liquid nitrogen for storing these cells. Armes said that if scientists want to tap the potential of stem cell therapy for regenerative medicine, they need to find simple, reliable, and cost-effective ways to prepare them. "Our gel may be useful in this regard, but it has not been proven."

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Mucin-Inspired Thermoresponsive Synthetic Hydrogels Induce Stasis in Human Pluripotent Stem Cells and Human Embryos

Source: Biopass

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