Heavy: genetic testing or will enter the implantable era

I still remember that when I saw wearable health equipment last year, I was in a whim. "There are now wearable devices that monitor heart rate, exercise status and blood sugar levels. If the human gene mutation status can be continuously monitored in real time, then How good is it.” With my limited IQ, the applications I can think of include early screening for cancer and post-treatment monitoring. If this is the case, the patient can always master his or her health. That is wonderful.

Of course, I always think that it is just a wonderful fantasy. Unexpectedly, the Ratnesh Lal team at the University of California, San Diego was realized. Scientists once again gave me a lesson with their research papers: "The dream is still there, if it is realized!" On June 13, the research results of the Lal team were published in the Proceedings of the National Academy of Sciences (1). ).

Heavy: genetic testing or will enter the implantable era

Professor Ratnesh Lal

In fact, the device developed by Lal is the same as 23andMe, which detects human-specific genetic mutation sites (SNPs). Although scientists are still not very clear about the role of most SNPs, scientists have also found special SNPs related to cancer, diabetes, heart disease, neurological diseases, autoimmune and inflammatory diseases. Professor Lal has developed an implantable chip that can detect SNPs related to disease in real time.

The structure of this chip is also very simple, that is, the probe that can find a special SNP is fixed to a graphene field effect transistor (FET). Once a specific SNP related to the disease appears, the probe captures them. The electric signal was generated at this moment. The chip then sends a signal to the phone to alert the user to a genetic mutation associated with the disease. At this time, we should put down our hands and go to the hospital for further inspection.

Heavy: genetic testing or will enter the implantable era

In principle, this device does not seem to differ much from traditional DNA chips except that it will have the ability to monitor and transmit signals in real time. In fact, this device is far from being so simple, and its kung fu is now in the details. In detail, it has three major advantages that are not available in SNPs testing equipment.

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