Crystallization refers to the process of precipitation of solid solutes from (s) saturated solution, including two steps of nucleation and crystal growth. It is an energy-efficient technique for separating, purifying, refining and controlling solid physical forms. Since more than 90% of the drugs exist in the form of crystals, crystallization technology is widely used in the field of pharmaceutical production. Drug crystallization plays an important role in the formation of particles in the pharmaceutical process and determines the stability and drug release properties of the final dosage form. The presence of impurities can adversely affect the efficacy of the drug, and the crystal structure of the crystal also affects the drug properties. How to improve the purity and quality of the crystal is very important. The main factors affecting the separation of drug crystals: 1 temperature When cooling the crystal, if the cooling rate is too fast, the solution quickly reaches a high saturation, and a large amount of minute crystals are formed, which affects the quality of the crystal product. 2 degree of mixing Increasing the agitation speed increases the nucleation and growth rate. 3 solvent and pH The solvent and pH should be such that the solubility of the target solute is low to increase the yield of crystallization. 4 the presence of impurities About IKA () IKA Group is the market leader in pre-laboratory, calorimetric analysis, mixed dispersion industrial technology. Magnetic stirrers, overhead stirrers, dispersion homogenizers, mixers, constant temperature shakers, grinders, rotary evaporators, Heating plates, calorimeters, laboratory reactors and other related products constitute the product line of IKA laboratory analysis, while industrial technology mainly includes mixing equipment for scale production, dispersion emulsification equipment, kneading equipment, and from pilot to expansion. The company's headquarters is located in Staufen, southern Germany. It has branches in the United States, China, India, Malaysia, Japan, Brazil and other countries. IKA was founded in 1910, and IKA Group can now proudly look back over the past 100 years. history. Nutrition supplements are mostly made into pills, tablets, capsules, granules or oral liquids, etc., and are taken alone with meals. They can be composed of amino acids, polyunsaturated fatty acids, minerals and Vitamins, or only composed of one or more vitamins; they can also be composed of one or more dietary ingredients, in addition to amino acids, vitamins, minerals. In addition to nutrients such as substances, there may also be herbs or other plant components, or concentrates, extracts or compositions of the above components. Nutrition Supplement,Food Grade Vitamin,Dietary Supplement,Nicotinamide Mononucleotide Capsule Hunan Insen Biotech Co., Ltd , https://www.insenhealth.com
When evaporating crystallization, the evaporation rate is too fast, the supersaturation of the solution is large, and minute crystals are formed, which affects the quality of the crystal product.
The stirring speed is too fast, which will cause the crystal to shear and break, which will affect the quality of the crystal product.
Solutes, ions in solution, polymers, etc. interfere with crystal rules
In the process of cooling and crystallization of the drug, the purity and quality of the crystallized product can be improved by slowing down the cooling rate and adjusting the appropriate stirring speed. Germany IKA provides you with the perfect crystallization process solution:
RC2 controlled refrigeration constant temperature circulator temperature is as low as -20 °C, temperature control accuracy is up to ±0.5 °C, which can realize program cooling, and online monitoring of cooling process, greatly improving the purity of drug crystals; with RW20 mechanical agitator or Eurostar series The electronic stirrer controls the stirring speed during the crystallization process to ensure the quality of the crystallized product. 
German IKA solution in crystallization process research