Release date: 2017-08-28

The nature of the body's inability to self-synthesize, the benefits of vitamins and the importance of supplementation are widely emphasized and mentioned, but a recent study raises questions about vitamin supplementation.

01. It is first discovered that vitamin intake leads to an increased risk of lung cancer.

The related research was published online in the oncology professional journal Journal of Clinical Oncology, a study of epidemiologists from the Ohio State University Comprehensive Cancer Center. The study showed that long-term high-dose supplementation with vitamin B6/B12, the energy supplement and metabolism promoter touted by the vitamin industry, increased the risk of lung cancer in men by 2-4 times compared with the control population. Men who smoke long-term supplements with this type of vitamin face a relatively higher risk of lung cancer.

Vitamin B6 is a component of certain coenzymes in the human body and is involved in a variety of metabolic reactions, especially in relation to amino acid metabolism. Clinical application of vitamin B6 preparations to prevent pregnancy vomiting and radiation sickness and vomiting. The main physiological function of vitamin B12 is to participate in the production of bone marrow red blood cells to prevent pernicious anemia; to prevent damage to the brain nerves.

The study is believed to be the first time scientists have discovered a specific link between vitamin intake and increased risk of lung cancer, and previous studies have suggested that these vitamin supplements can reduce people's risk of cancer to some extent.

02, tracking nearly 80,000 data, up to 10 years

In order to verify the hypothesis that B vitamins can reduce cancer risk, the researchers conducted in-depth research on the data of more than 77,000 participants in the prospective cohort study of VITamins And Lifestyle (VITAL). In assessing the correlation between vitamins and other minerals and cancer risk. All participants ranged in age from 50 to 76 years and were recruited from 2000 to 2002. According to the research requirements, all study participants need to report to the researchers about the use of vitamins for 10 years.

At the same time, researchers used statistical knowledge to measure the link between multiple factors and lung cancer risk, including: personal smoking history, age, ethnicity, education, body size, alcohol intake, and family history of lung cancer.

03, the prevalence of lung cancer increased by 4 times

The study data strongly suggest that male smokers who take more than 20 mg of vitamin B6 or 55 mg of vitamin B12 per day for 10 years have a significantly increased risk of developing lung cancer. Male smokers who took vitamin B6 or vitamin B12 at this dose were three to four times more likely to develop lung cancer than those who did not.

"Our data show that taking high doses of vitamin B6/B12 for a long time can lead to an increase in the incidence of lung cancer in male smokers. Although this finding still needs further confirmation and evaluation, this study does clearly reflect this. The facts," explains Brasky, the lead author of the research article.

04. There are gender differences in the effects of vitamin B on cancer.

The main author of the article, Brasky, emphasized that the vitamin B6/B12 supplementation dose of the population covered by the study is much higher than the standard amount required by the human body.

At the same time, the researchers further confirmed the association between long-term high-dose intake of vitamin B6/B12 and increased risk of lung cancer in men by conducting two other studies. The long-term high-dose vitamin B6/B12 intake has been shown to promote cancer risk in another independent male population, confirming that menopausal women do not have an increased risk of lung cancer after long-term high-dose doses of this type of vitamin.

05, vitamin B reduces the "gene damage" of PM2.5

Scientists have long suspected that PM2.5 harms human health by causing epigenetic changes in cells. A previous study published in PNAS demonstrated that vitamin B plays an important role in reducing the effects of air pollution on the epigenome.

In this human trial, a team of scientists from multiple countries would like to see if daily intake of multivitamin B containing 2.5 mg folic acid, 50 mg vitamin B6 and 1 mg vitamin B12 can reduce exposure to a certain concentration of PM2.5. The toxic reaction caused. First, placebo was administered to 10 volunteers in clean air as a control basis, and then the same volunteers were placed in a high concentration of PM2.5 air and given a large dose of vitamin B. After 4 weeks of continuous use, the study found that vitamin B reduced the damage of PM2.5 to 10 localized genes by 28%-76%. They also found the same damage-reducing effect on mitochondrial DNA that produces energy for cells. It is worth noting that the author of the article also emphasized the limitations of this research work.

Source: Sina Pharmaceutical News

Polyphenol

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