DNA damage reveals new anti-cancer therapies September 06, 2015 Source: Bio Valley Every organism in nature will protect its DNA at any cost, but how to accurately distinguish the damage of its own DNA or the damage of foreign DNA invading the virus remains a mystery. It was published in a research paper published in the international magazine Cell . Researchers at the Salk Institute have revealed through research that the cellular response system accurately distinguishes between the two threats described above, and related research may help develop new cancer-selective viral therapies that can also help understand why aging and certain diseases seem to Always open the door to viral infections. Researcher Professor Clodagh O'Shea said that this study clarifies a basic mechanism by how the body distinguishes between DNA breaks in cells and viral genomes to induce different immune responses that protect the host. This study may help explain why a particular situation For example, aging, cancer chemotherapy, and inflammation make our body more susceptible to viral infections. Many factors trigger DNA breaks, and the researchers clarified how a series of proteins called MRN complexes detect DNA and viral rupture and amplify this effect by histones; the MRN complex protein turns on a domino The domino effect, which activates histones around the chromosome, ultimately triggers a wide range of effects to help the body's cells repair DNA. In general, a common DNA virus enters the host nucleus and initiates the expression of a gene that replicates its own DNA, while the host cell detects this unauthorized replication, and the MRN complex does not induce a broad response to killing cells. Selectively neutralize the DNA of the virus under the precursor, the MRN's response to the virus will stay locally and will only selectively inhibit the virus; if the invading virus triggers a similarly strong reaction, the cells will frequently pause growth. . In the article, the researchers developed a new type of virus that can be destroyed in normal cells, but can replicate specifically in cancer cells, unlike normal cells, which almost always contain high levels of DNA damage in cancer. In cells, MRN may respond to DNA rupture, but engineered viruses may be able to escape surveillance. Cancer cells always have a high mutation rate, and there will be genomic instability at an early stage, so we can imagine how difficult it is to build a virus to destroy early body damage and as a preventive measure. Safety shoes
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DNA damage reveals new anti-cancer therapies