Release date: 2018-05-23

Latest discoveries and innovations

What changes will artificial intelligence bring to the bio-industry? The Wubian team of the Institute of Microbiology, Chinese Academy of Sciences took the lead in this field to create a type of biocatalytic reaction that does not exist in nature through intelligent computing technology, and for the first time in the world to complete the construction of industrial grade strains through calculation. On the 22nd, the results were published online in the internationally renowned journal Nature and Chemical Biology.

“The structure and folding method of protein is very large. It can only be screened through the laboratory. Now, after the intervention of artificial intelligence calculation technology, the data can be processed quickly and in large quantities.” Wu Bian, a researcher and author of the Institute of Microbiology, Chinese Academy of Sciences, said that in 2017, American Chemistry will list the new protein structure of artificial intelligence as the top of the eight scientific breakthroughs of the year.

If an industrial strain is likened to a car, the enzyme protein is its core engine. After redesigning the aspartase molecule, the researchers successfully obtained a series of artificial β-amino acid synthetases with absolute positional selectivity and stereoselectivity. Subsequently, the team integrated non-native enzymes into E. coli to construct an engineered strain that efficiently synthesized β-amino acids.

"β-lactam antibiotics, paclitaxel (anticancer drugs), sitagliptin (diabetes drugs) and many other star molecules with huge market sales require β-amino acids as a synthesis unit." Wubian told Science and Technology Daily reporter The synthesis of β-amino acids has long relied on transition metal catalyzed chemical pathways, requiring expensive catalysts, harsh reaction conditions, and the like.

Wu Bian said that through the optimization of the fermentation process and the optimization of the conversion process, the biocatalyst system can utilize the cheap and easily available olefinic acid raw materials and ammonia water under mild conditions to realize the synthesis of the corresponding β-amino acid in one step, and the cost can be reduced by 50%. 90%.

According to reports, the technology has been completed in the pilot and full-scale production process verification, the potential market of the product is expected to exceed 3 billion yuan, is expected to be in the production of anti-cancer and AIDS therapeutic drugs such as paclitaxel, dulutvir and Malawi. Significantly reduce production costs.

Source: Technology Daily

Breast Pump Accessories

NINGBO YOUHE MOTHER&BABY PRODUCTS CO.,LTD , https://www.oembreastpump.com