Author: Feng Weidong Date: 2018-07-23 According to a paper published online in the journal Science Report on the 18th, scientists at the New York Stem Cell Foundation (NYSCF) Institute have developed a new bone engineering technology called Segmental Addition Tissue Engineering (SATE). The technology allows researchers to work together to create large-scale, personalized grafts that make it possible to strengthen treatment of patients with bone diseases or bone injuries through regenerative medicine. The problem of bone defects caused by disease or injury is becoming more and more serious. The current treatment method is to use synthetic substitutes or obtain bone grafts from other parts of the patient's body. However, these treatments often trigger immune rejection and fail to form the connective tissue or vasculature required for functional bone. Bone grafts produced by patient stem cells can rule out these limitations, but it is difficult to create the exact size and shape of the graft needed to treat large defects. The solution for the new study was to design smaller joints separately and then combine them. In the experiment, the researchers designed grafts for rabbits with femoral defects, and femoral defects affected 30% of the total bone volume of rabbits. They first scan the femur to assess the size and shape of the defect and generate a transplant model, then divide the model into smaller parts and create custom brackets for each part. The researchers placed these scaffolds in a bioreactor with human-induced pluripotent stem cell-derived mesoderm progenitors, which are specifically designed to accommodate bone grafts of various sizes, ensuring uniform tissue throughout the graft. development. Once the cells are integrated and grown within the scaffold, the biocompatible bone cement or other orthopedic device can be used to combine the segments of the bone graft into an entire, mechanically stable graft. According to the researchers, SATE is a standardized, universal technology that is easy to implement, allowing bioengineered bone grafts to move from laboratory to clinical faster. Susan Solomon, CEO of NYSCF, said that millions of people suffer from bone damage due to trauma, cancer, osteoporosis, osteonecrosis and other destructive diseases, and SATE technology is expected to improve their lives. Editor-in-chief Simply put, SATE technology combines the smaller bone segments designed by stem cells to produce large individualized grafts, overcoming the limitations of graft size and shape grown in the laboratory. This new type of skeletal engineering is likely to improve the treatment of bone defects caused by injuries or diseases in the future. For the suffering patients, today's results are a new hope. Source: Technology Daily 100% cotton Surf Poncho, 100% polyester surf poncho, recycled waffle towel robe, dry robe poncho are all available.
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New bone engineering technology is expected to be used for personalized transplantation