Jilin University scientists extract anti-gout active ingredients from sunflower disk

Jilin University scientists extract anti-gout active ingredients from sunflower disk

July 5, 2018 Source: Xinhua News Agency Author: Meng Qi with, Zou Sheng-wen

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The reporter recently learned from Jilin University that Liu Xiaobo, a professor at the College of Life Sciences of Jilin University, extracted anti-gout active ingredients from the sunflower disk. This achievement has been published in domestic professional medical journals such as Medicine and Health, and has obtained two national invention patents.

Gout is caused by disturbances in the metabolism of sputum in the human body, increased or decreased uric acid synthesis, resulting in hyperuricemia, severe joint disability and renal insufficiency, and diabetes in the medical world as "undead cancer." According to statistics, the number of patients with hyperuricemia in China has reached 170 million, and the number of patients with gout has exceeded 80 million. It is increasing rapidly with an annual growth rate of 9.7%.

There is no effective treatment and method for gout at present. Most commonly used drugs at home and abroad are inhibiting sputum metabolism and reducing uric acid. However, this type of treatment is helpless for urate crystals (gout), and the patient's urate crystals accumulate in the body. The more the joints cause swelling and pain, which seriously endangers human health. Moreover, most of the existing drugs for treating gout cannot overcome the side effects of the drug itself on liver and kidney damage of the drug users.

"Resolving gout requires breaking through three difficult problems: rapid and safe uric acid reduction, dissolving tophi, and not hurting the liver without hurting the kidney." Professor Liu Xiaobo said.

After five years of research and development, Liu Xiaobo team extracted alkaloids, flavonoids, small peptides and other active ingredients from the sunflower disk planted in saline-alkali soil. Pharmacological and pharmacodynamic analysis showed that alkaloids have a therapeutic effect on gout, which can specifically form uric acid to form a sunflower uric acid complex. After being metabolized by the liver, it can be excreted by the kidney to rapidly reduce uric acid. Small peptides can be directly absorbed by the intestinal tract. Preparation, can enter the blood to regulate uric acid metabolism and renal tubular transporter, control uric acid production, increase uric acid excretion, dissolve tophi; flavonoids inhibit inflammatory cell chemotaxis and reduce inflammatory factor release, unique for acute episodes of gout arthritis Anti-inflammatory, swelling and pain relief effects.

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