Japanese researchers said on the 16th that retinal edema occurred after a patient with an eye disease transplanted retinal cells from allogeneic induced pluripotent stem cells (iPS cells) last year. This is the first complication after the clinical study.

iPS cells are stem cells that are "reprogrammed" by mature somatic cells and have similar differentiation potential to embryonic stem cells. Compared with the use of the patient's own iPS cells, the cost and time required to grow into tissue cells after transplantation with allogeneic iPS cells will be greatly reduced, so related research has attracted much attention in the medical field.

In March last year, researchers from the Institute of Physical Chemistry of Japan announced the completion of the world's first such transplant, transplanting retinal cells grown from allogeneic iPS cells into the right eye of a 60-year-old male with age-related macular degeneration. Since then, they have performed similar transplants for four elderly patients with macular degeneration.

However, the researchers admitted on the 16th of this month that one of the 70-year-old male patients developed retinal edema. Although there was no need for urgent treatment, it was also hopeless. Therefore, they performed retinal anterior membrane stripping surgery on the patient on the 15th. .

Gao Qiaozheng, the project leader of the Institute of Physical and Chemical Research, said that this situation cannot be denied a causal relationship with the use of iPS cells, but this matter will not affect the relevant research progress. (Technology Daily)

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