Release date: 2009-04-13

Recently, a team led by David Hess, a professor at the Roberts Institute of the University of Western Ontario in Canada, used human bone marrow stem cells to generate new blood vessels in experimental mice. This result is expected to be applied to the treatment of human diseases such as peripheral arterial diseases.

The researchers extracted stem cells from human bone marrow and isolated three different types of "angiogenic stem cells," which were then "purified" to screen out stem cells that were contaminated or could cause infection. The stem cells were injected into the experimental rat circulatory system. The researchers have previously ligated one of the arteries in the legs of these rats, causing partial damage to the legs. They found that stem cells that were injected into the circulatory system of the experimental rat gathered in the ischemic area of ​​their legs and contributed to the repair of damaged blood vessels, improving the blood circulation of the experimental rats. Hess believes that the study is clinically feasible, and a biopharmaceutical company in the United States has applied to the US Food and Drug Administration for the clinical outcome of 21 patients with advanced peripheral arterial disease at a medical center in Houston. test. Hess said the findings could also be used to treat ischemic symptoms in other parts of the body.

Peripheral arterial disease is an atherosclerotic disease and is one of the most common serious complications in diabetic patients. The main symptom is limb ischemia, which can lead to limb pain, difficult to heal, and severe amputation. Shanghai Medical Device Industry Association

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