Lack of antibody diversity or making older people more susceptible to the flu February 22, 2019 Source: Health News Network The reporter learned from the Cell Marketing Department's China Marketing Department that on February 20th, the journal Cell-Host and Microorganism published a new discovery: the reason why the flu vaccine may be less effective in the elderly population, mainly with the implementation of humoral immunity B Lymphocytes are involved, and it is difficult for B cells to produce antibodies that are sufficiently adapted and resistant to emerging influenza strains. As we age, B cells and their secreted antibodies are reduced, and in the face of changing influenza viruses, there is no effective protection. This study suggests that vaccines that promote the production of protective mutations in B cells are a priority for improving influenza immunity in the elderly. The weakening of the immune system by aging has been recognized as a major cause of illness and death in the elderly. The vast majority of deaths caused by influenza occur in the elderly over 65 years of age, and the antibody response to the elderly is significantly reduced after the flu vaccine. For this reason, influenza is one of the leading causes of death among the elderly, and vaccination can only protect some elderly people. To explore its underlying mechanisms, the paper's correspondent, University of Chicago professor Patrick Wilson and his team compared the responses of older and younger B cells and antibodies to vaccination of different influenza strains. The results showed that young people's B cells continued to accumulate recent mutations, but the B cells of the elderly remained basically unchanged, lacking corresponding adaptability, and it was difficult to cope with the emergence of different influenza strains. "The main inference of the study is that when the newly-populated influenza virus infects the elderly, because the protection of antibodies in the elderly is insufficient, they do not have enough 'weapons' to fight the flu." Patrick Wilson introduced the antibodies to the elderly. Cross-reactive memory B cells from early life have low adaptability to new influenza strains, and have a higher affinity for historical strains that are prevalent during childhood, and for modern strains that are closer to current times. Low affinity. The antibodies of the elderly can only target some of the conserved proteins and structures of the influenza virus, and respond to fewer mutations, which is not enough to effectively cope with the evolving virus. In contrast, antibodies from young people are better able to recognize new mutant molecules on influenza viruses. Fire Alarm By Bedroom,Bedroom Fire Alarm,Bedroom Fire Alarms,Bedroom Monoxide Alarm Guangdong Isafenest Co.,Ltd. , https://www.isfenest.com
Lack of antibody diversity or making older people more susceptible to the flu