Food Machinery Chinese medicine crusher refers to mechanical equipment used in the fields of medicine, food, chemical industry, etc. It is used and seen in some pharmacies and households. The remarkable advantage of the Chinese medicine pulverizer is high work efficiency and simple operation. It belongs to batch pulverization, and the pulverization amount ranges from 100g to 500g. The Chinese medicine pulverizer is smashed because it is a traditional Chinese medicine, so it is pulverized on the basis of not destroying the performance of the drug. Such working conditions require that the technology of the pulverizer needs to be further improved in some aspects, and several types that are currently common in the work. The technical problems are: powder aggregation, problems in the chemical extraction process, problems in the determination of dissolution in vitro, and problems in solving pharmacodynamic validation. The following article provides a detailed analysis of these four types of technical issues.

Solve the problem of powder aggregation

After the ultra-micronization, the specific surface area of ​​the drug is significantly increased, and the surface energy is high, so that there is a strong mutual attraction and a stable tendency. In order to prevent the powder from being aggregated in a monodisperse state, suitable surface treatment and packaging techniques can be employed.

Solve problems in the chemical extraction process

Because the application of traditional Chinese medicine is no more than two ways: extraction and direct medicine. From the perspective of extraction, there are two problems, one is the dispersion of powder, and the other is the gelatinization problem in the extraction process. This requires screening and optimization of extraction process parameters (including extraction temperature, extraction time, extraction solvent type, etc.) ) to solve.

Solve problems in the determination of dissolution in vitro

From the point of view of direct injection of Chinese medicine into the medicine, the core problem of the preparation made of ultrafine Chinese medicine powder is the establishment of in vitro dissolution technology. After analysis, it is considered that in order to solve such technical problems, it is necessary to conduct a methodological investigation of the dissolution medium, the dissolution method, and comprehensive selection of the indicator components.

Solve the problem of pharmacodynamic verification

The principle of pharmacodynamics is the most powerful means of verifying whether the active ingredients are preserved and enhancing the efficacy of the Chinese medicine after pulverization. The idea that Chinese medicine is pulverized can significantly improve the pharmacodynamic activity of medicinal materials, experts believe that it remains to be studied and verified.

In China, the introduction of airflow pulverization technology for Chinese medicine pulverizers has begun. The traditional Chinese medicines through airflow pulverization technology are limited to some unique and valuable fine Chinese medicines. The airflow pulverizer is an innovative pulverization technology process, and its extraction method is more and more simplified. The time is getting shorter and shorter. The emergence of the new Chinese medicine pulverizer greatly saves the production time and production cycle, improves the utilization of raw materials of traditional Chinese medicine, and brings practical effects and new technologies to the processing and production of traditional Chinese medicine.

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