Drug Intermediates -Pharmaceutical intermediates: A material that is produced during a process step of the drug substance and must undergo further molecular changes or refining before it becomes a drug substance. The intermediates can be separated or not separated.
Active Pharmaceutical Ingredient (APIS)(or Drug Substance) : Active Pharmaceutical Ingredient (API)(or Drug Substance) : Any substance or mixture of substances intended to be used in the manufacture of pharmaceutical products and, when used in pharmaceutical products, to be an active ingredient in pharmaceutical products. Such substances have pharmacological activity or other direct effects in the diagnosis, treatment, symptom relief, management or prevention of disease, or can affect the function and structure of the body. As can be seen from the definition, the Intermediates APIS is a key product of the previous process of manufacturing the API and has a different structure from the API
Finally, for example, amoxicillin capsules are called preparations, amoxicillin is called APIS, and 6-APA is called Veterinary Intermediates APIS.
Penicillin potassium for injection is called preparation, penicillin potassium is called Veterinary raw materials, and green potassium industrial salt is called intermediate
Pharma intermediates,Pharmaceutical intermediates,intermediate api ,apis and intermediates NANYANG CHENGPENG PHARMACEUTICAL CO.,LTD , https://www.chppharm.com
A new method for sterilization of edible fungi
Take one of the old petrol tanks (the inside of which is to be cleaned), first build a 10 cm higher than the barrel, 10 cm wider than the barrel, and use ten 16 mm thick, 30 cm long steel bars as the bar Left blower ducts on one side. One steel pipe is welded on the barrel wall and the valve is installed to add water and sewage; on the other side of the barrel wall, two pipes (on the black hose) are welded on the other side of the barrel wall; A 4 cm long L-shaped steel pipe is welded to the upper and lower sides, and a transparent plastic pipe is used as a water level gauge. The oil drum is then placed on the furnace table. When placing, pay attention to the bucket lid forward, the bottom of the bucket back, the front low and back high. Rely on the smokestacks at the bottom of the barrel to make full use of the residual heat; build the furnace walls on both sides to enclose the lower half of the oil barrel. Such a simple steam generator is successful. Place a piece of concrete on the side of the hearth or spread two layers of film (the area depends on the material, the top is covered with bricks or wooden rods, then the material is stacked, the exhaust tube is placed under the pile, and the upper cover is covered with 3-4 layers of film. The bricks are pressed well, and then the fire is started, and the steaming time is 6-8 hours, after which the stockpiles are froze overnight and then inoculated. Such a stove top can also be built in the mushroom shed, and only the oil barrels can be moved in winter. In the shed, steam can be used to warm it up, and it can be used in one furnace. When the production task is tight, a stack of material can be installed on the other side of the furnace table. The two stacks are sterilized in turn, which saves coal and saves time and labor. Pot is convenient, economical and practical.