Whether the adult brain can renew the controversy

Whether the adult brain can renew the controversy

April 02, 2019 Source: Health News

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According to Xinhua News Agency, Beijing, April 1 (Reporter Huang Wei) As people grow older, people often sigh that the years have passed and their brains have become bad. Then, from the perspective of brain cells, are the brain neurons less and less likely to be reborn? This issue has recently become the focus of discussion in the scientific community, because a new study suggests that even in the age of eighty or ninety, the human brain is still forming new neurons.

According to a paper published in the new issue of the journal Nature Medicine, Spanish researchers analyzed a sample of brain tissue donated by a group of people aged 43 to 87, in which new neurons were detected. The number of these new neurons did decrease with age, and the youngest in the study sample had 30% fewer newborn neurons than the youngest.

The scientific community has been controversial about whether the hippocampus of the human brain, especially related to learning and memory, can regenerate neurons in adulthood. A heavy paper published in the British journal Nature last year said that analysis of brain tissue samples donated by some deceased or brain-operated patients showed that newborn neurons can be found in the hippocampus of children's brains, but in adult brain samples. Can't find it at all.

The conclusions of the two studies are at odds, and it is speculated that different results may stem from different detection methods. The author of the latest paper, Maria Laurent-Martin of the Severo Ochoa Center for Molecular Biology in Spain, said that if brain tissue is kept in chemicals for too long, new neurons may not be detected, and they analyze It is a sample taken within 24 hours after the donor died.

The author of Nature, Shawn Sollers of the University of Pittsburgh, believes that Laurent-Martin’s views are not convincing because they analyzed that two of the samples were only stored for five hours in the chemical. No new neurons were detected in the brain tissue. Sorels also believes that the DCX protein labeling method used in the latest study does not ensure that newborn neurons are detected in adult brain tissue.

The new issue of Nature published an editorial in this regard, saying that the scientific debate will continue. If future research can confirm that newborn neurons can also be born in the brain, it will help develop new therapies such as Alzheimer's disease, which is related to the death of brain neurons.

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