Using drugs to suppress appetite and promote heat-producing combination therapy to make obese mice lose weight successfully November 14, 2018 Source: Science and Technology Daily Author: Zhang Meng Ran A medical study published in the journal Nature News recently reported that the use of drugs against nicotine (also known as nicotine) and cold exposure signaling pathways has been shown to reduce mouse body weight and improve metabolic health in mice. The compounds icilin and dimethylphenylpiperazine stimulate the appetite suppressor pathway and the heat-promoting pathway, thereby regulating systemic energy balance to promote weight loss in obese mice. Obesity is characterized by an abnormal increase in the percentage of body fat and body weight caused by an increase in the volume and number of cells of fat cells in the body. This is actually a risk factor for metabolic diseases such as diabetes, which poses a major threat to health. Smoking and "cold exposure" are environmental regulators of energy metabolism in the body that suppress appetite and increase energy expenditure. At present, people are seeking to increase the heat production by means of drugs, hoping to simulate "cold exposure" and increase energy consumption, thereby promoting weight loss. However, the simultaneous increase in food intake usually offsets these effects. This time, the Helmholtz Munich Research Center - German Environmental Health Research Center scientist Marcias Chepp and colleagues, used a combination therapy - the simultaneous use of nicotinic acetylcholine receptor α3β4 and transient voltage receptor cations Channel M8 (TRPM8), TRPM8 can be activated by small molecule therapy at low temperatures. The team found that this treatment reduced the body weight of obese mice and corrected glucose intolerance. The researchers point out that the above findings open up a potentially new way to treat obesity, and that this treatment does not have the negative health consequences associated with cigarette smoke. However, further research is needed to determine whether these findings can be translated into humans. Hi Vis vest,Type R,Black Bottom,Safety Vests Ningbo Staneex Imp. & Exp. Co., Ltd. , https://www.staneex.com
Using drugs to suppress appetite and promote heat-producing combination therapy to make obese mice lose weight successfully