Successfully developed a strong tissue adhesive glue that can seamlessly repair "crunchy" cartilage December 04, 2018 Source: Ministry of Science and Technology Articular cartilage defects still have no effective treatment due to lack of self-healing. Traditional therapies such as bone marrow stimulation techniques and joint replacement are effective in relieving pain, but they can no longer produce healthy hyaline cartilage with normal morphology and function. In addition, because these treatments cannot reverse cartilage damage, the site of injury may deteriorate and require a second operation, which may result in joint dysfunction and permanent disability. Today, cartilage tissue engineering has become another promising approach to repair cartilage defects. However, the required materials often cause blockage of cartilage regeneration due to lack of effective tissue integration, while the poor mechanical properties of conventional hydrogels result in the lack of mechanical properties of the regenerated tissue that match the normal tissue. Therefore, it is currently the biggest challenge to find materials with good tissue integration characteristics and strong mechanics for in situ osteochondral defect repair. In response to this problem, Professor Ouyang Hongwei of Zhejiang University School of Medicine has prepared a hydrogel (MOG) with in-situ formation and seamless integration of tissue to better repair osteochondral defects. The hydrogel has the following characteristics: 1. Injectable in situ molding can promote the integration of colloid and tissue; 2. Adjustable mechanical properties, simulate the mechanical properties of natural cartilage, and the Young's modulus is close to that of natural cartilage explants (0.4MPa); 3. Strong tissue integration, the aldehyde group on the hydrogel is bonded to the amino group of the protein on the tissue, and the two are tightly integrated, which is beneficial to the migration of host cells and the formation of new tissue; "No trace" repair, the hydrogel can effectively repair osteochondral defects, and the new cartilage and the in situ cartilage seamlessly connected (new cartilage and in situ cartilage can not be effectively integrated will lead to cartilage repair failure, which is also currently A common problem with cartilage repair), while the Young's modulus of new cartilage is close to that of natural cartilage. The work was supported by projects such as the National Key R&D Program and the National Natural Science Foundation. The results paper "Tough hydrogel with enhanced tissue integration and in situ forming capability for osteochondral defect repair" was recently published on Applied Materials Today.
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Successfully developed a strong tissue adhesive glue that can seamlessly repair "crunchy" cartilage