Peptide Lyophilized Powder Myostatin Growth Differentiation Factor 8 / Gdf-8 / Gdf8
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Model NO.: GDF-8
Product Name: Growth Differentiation Factor 8
MOQ: 1kit
Appearance: Sterile Filtered White Lyophilized Powder
Storage: Dry Cool Place
Trademark: HZ
Transport Package: According to Every Customers′ s Requirements
Specification: 10vials/kit
Origin: China
HS Code: 3001200020
Model NO.: GDF-8
Product Name: Growth Differentiation Factor 8
MOQ: 1kit
Appearance: Sterile Filtered White Lyophilized Powder
Storage: Dry Cool Place
Trademark: HZ
Transport Package: According to Every Customers′ s Requirements
Specification: 10vials/kit
Origin: China
HS Code: 3001200020
Peptide Lyophilized Powder Myostatin Growth Differentiation Factor 8 / Gdf-8 / Gdf8 (1mg/Vial)


Product name: Myostatin GDF-8
Purity: 95%+
Specification: 1mg/vial
Appearance: Sterile Filtered White Lyophilized Powder
Storage: Dry Cool Place
Grade: Medicine Grade


Product Description

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.


Discovery and sequencing

The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.


Structure and mechanism of action

Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.

Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.


Our Advantage:
Customs clearance Don't have to worry about customs pass rate,our customs clearance is 100%
Product packing Discreet package .The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .
After-sales service Warm after-sale service for you 24/7. Any of your question would be solved for the
first as soon as possible.
Security shipping Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional
forwarder would be recommanded for you.
Delivery time We have stock, so we can delivery quickly at the very day when receive the payment.
Condition payment Western union, money gram, T/T


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Peptide Lyophilized Powder Myostatin Growth Differentiation Factor 8 / Gdf-8 / Gdf8 (1mg/Vial)


Product name: Myostatin GDF-8
Purity: 95%+
Specification: 1mg/vial
Appearance: Sterile Filtered White Lyophilized Powder
Storage: Dry Cool Place
Grade: Medicine Grade


Product Description

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.


Discovery and sequencing

The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.


Structure and mechanism of action

Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.

Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.


Our Advantage:
Customs clearance Don't have to worry about customs pass rate,our customs clearance is 100%
Product packing Discreet package .The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration .
After-sales service Warm after-sale service for you 24/7. Any of your question would be solved for the
first as soon as possible.
Security shipping Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional
forwarder would be recommanded for you.
Delivery time We have stock, so we can delivery quickly at the very day when receive the payment.
Condition payment Western union, money gram, T/T


Hot Selling Peptides Lists :
 
Product name Specification Packing
H GH 176-191 2mg/vial 10vials/kit 1g/bag
GR RP-2 5mg/vial 10vials/kit 1g/bag
GR RP-2 10mg/vial 10vials/kit 1g/bag
GR RP-6 5mg/vial 10vials/kit 1g/bag
GR RP-6 10mg/vial 10vials/kit 1g/bag
MGF 2mg/vial 10vials/kit 1g/bag
PEG MGF 2mg/vial 10vials/kit 1g/bag
CJC-1295 with DAC 2mg/vial 10vials/kit 1g/bag
CJC-1295 without DAC 2mg/vial 10vials/kit 1g/bag
PT-141 10mg/vial 10vials/kit 1g/bag
Melanotan-1 10mg/vial 10vials/kit 1g/bag
Melanotan-2 10mg/vial 10vials/kit 1g/bag
Ipamorelin 2mg/vial 10vials/kit 1g/bag
Hexarelin 2mg/vial 10vials/kit 1g/bag
Sermorelin 2mg/vial 10vials/kit 1g/bag
Oxytocin 2mg/vial 10vials/kit 1g/bag
TB500 2mg/vial 10vials/kit 1g/bag
Pentadecapeptide BPC 157 2mg/vial 10vials/kit 1g/bag
Triptorelin 2mg/vial 10vials/kit 1g/bag
Gonadorelin 2mg/vial 10vials/kit 1g/bag
Gonadorelin 10mg/vial 10vials/kit 1g/bag
Tesamorelin 2mg/vial 10vials/kit 1g/bag
DSIP 2mg/vial 10vials/kit 1g/bag
Selank 5mg/vial 10vials/kit 1g/bag
Adipotide 1g/foil bag 1g/foil bag
Thyrotropin TRH 1g/foil bag 1g/foil bag
Epitalon 10mg/vial 10vials/kit 1g/bag
Deslorelin 20mg/vial 10vial/kit 1g/bag
Follistatin 315 1mg/vial 1mg/vial 10vials/kit
Follistatin 344 1mg/vial 1mg/vial 10vials/kit
ACE 031 1mg/vial 1mg/vial 10vials/kit
GDF-8 1mg/vial 1mg/vial 10vials/kit
     

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