Hot Selling Pharmaceutical Raw Material Azelastine Hydrochloride CAS 79307-93-0

Model NO.: 79307-93-0
CAS: 79307-93-0
Mf: C22h25cl2n3o 
MW: 418.36
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 2937290090
Model NO.: 79307-93-0
CAS: 79307-93-0
Mf: C22h25cl2n3o 
MW: 418.36
Trademark: YCGC
Transport Package: Foil Bag
Specification: 10g
Origin: China
HS Code: 2937290090
Details

Product Name: Azelastine hydrochloride 
Synonyms: a5610;azeptin;e-0659;w-2979m;AZELASTINE HCL;AZELASTINE HYDROCHLORIDE;4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one hydrochloride;4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride 
CAS: 79307-93-0 
MF: C22H25Cl2N3O 
MW: 418.36
Product Categories: Antihistaminic;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor;Astelin
Melting point  225--229ºC
Storage temp. : Keep in room temperature . 
Stability: Incompatible with strong oxidizing agents. 
Chemical Properties White Crystalline Powder 
Usage Orally active H1-hystamine receptor antagonist. Antihistaminic.



Description

Astelin (azelastine hydrochloride) Nasal Spray, 137 micrograms (mcg), is an antihistamine formulated as a metered-spray solution for intranasal administration. Azelastine hydrochloride occurs as a white, almost odorless, crystalline powder with a bitter taste. It has a molecular weight of 418.37. It is sparingly soluble in water, methanol, and propylene glycol and slightly soluble in ethanol, octanol, and glycerine. It has a melting point of about 225°C and the pH of a saturated solution is between 5.0 and 5.4. Its chemical name is (±)-1-(2H)-phthalazinone,4-[(4chlorophenyl) methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride.

Astelin Nasal Spray contains 0.1% azelastine hydrochloride in an aqueous solution at pH 6.8 ± 0.3. It also contains benzalkonium chloride (125 mcg/mL), edetate disodium, hypromellose, citric acid, dibasic sodium phosphate, sodium chloride, and purified water.

After priming [see DOSAGE AND ADMINISTRATION], each metered spray delivers a 0.137 mL mean volume containing 137 mcg of azelastine hydrochloride (equivalent to 125 mcg of azelastine base). The bottle can deliver 200 metered sprays.



Hot Selling Pharmaceutical Raw Material Azelastine Hydrochloride CAS 79307-93-0


Application

This medication is used to treat itching eyes caused by allergies (allergic conjunctivitis). Azelastine belongs to a class of drugs known as antihistamines. It works by blocking certain natural substances called histamines that are responsible for allergic symptoms.
 
Azelastine nasal spray is indicated for the local treatment of the symptoms of seasonal allergic rhinitis and perennial allergic rhinitis, such as rhinorrhea, sneezing and nasal pruritus in adults and children 5 years of age and older. In some countries, it is also indicated for the treatment of vasomotor rhinitis in adults and children ≥ 12 years old. Azelastine eyes drops are indicated for the local treatment of seasonal and perennial allergic conjunctivitis.Uses for Azelastine HydrochlorideSeasonal Allergic RhinitisSymptomatic treatment of seasonal allergic rhinitis (e.g., hay fever). Intranasal azelastine is at least as effective as oral antihistamines (e.g., cetirizine) or intranasal corticosteroids.May provide improvement of ocular manifestations, possibly secondary to systemic absorption of the drug.Nonallergic RhinitisSymptomatic treatment of nonallergic (vasomotor) rhinitis;Allergic ConjunctivitisSymptomatic relief of ocular itching associated with allergic conjunctivitis.


Dosage

Available as azelastine hydrochloride; dosage expressed in terms of the salt.1
When properly primed, the nasal spray pump delivers approximately 100 metered doses per bottle.Pediatric PatientsSeasonal Allergic RhinitisIntranasalChildren ≥12 years of age: 2 sprays (274 mcg) in each nostril twice daily.

Children 5-11 years of age: 1 spray (137 mcg) in each nostril twice daily.Nonallergic RhinitisIntranasalChildren ≥12 years of age: 2 sprays (274 mcg) in each nostril twice daily.Allergic ConjunctivitisOphthalmicChildren ≥3 years of age: 1 drop of a 0.05% solution in the affected eye(s) twice daily.AdultsSeasonal Allergic RhinitisIntranasal2 sprays (274 mcg) in each nostril twice daily.Nonallergic RhinitisIntranasal2 sprays (274 mcg) in each nostril twice daily.Allergic ConjunctivitisOphthalmic1 drop of a 0.05% solution in the affected eye(s) twice daily.



Side Effect

Azelastine is safe and well tolerated in both adults and children with allergic rhinitis. Bitter taste, headache, nasal burning and somnolence are the most frequently reported adverse events. US prescribing recommendations warn against the concurrent use of alcohol and/or other central nervous system depressants, but to date there have been no studies to assess the effects of azelastine nasal spray on the CNS in humans.

More recent studies have shown similar degrees of somnolence (approx. 2%) compared with placebo treatment. The problem of bitter taste may be reduced by correct application of the nasal spray (i.e. slightly tipping the head forward and not inhaling the medication too deeply), or alternatively using the azelastine/sucralose formulation.



The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.

2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.

3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.

b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.

4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.


Our advantage

1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.



FAQ
Order Guide
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Paypal or  Moneygram

Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.

We specialized in manufacturing high quality and reliable raw material 
which are widely used in the fields of food, health, cosmetics, pharmaceuticals, and Bodybuilding
 
we have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .
please donot hesitate to contact us.



More Hot  Sale  Product:
Mirtazapine 85650-52-8
Trazodone Hydrochloride 25332-39-2
Phenibut 1078-21-3
Tianeptine Sodium 30123-17-2
NSI-189 Phophate 1270138-41-4
5-Hydroxytryptophan 4350/9/8
Sunifiram 314728-85-3
   
Armodafinil 112111-43-0
CRL-40,940 90280-13-0
Zopiclone  43200-81-3
Ginkgo biloba /
Huperzine A 120786-18-7
CDP-Choline/Citicoline 987-78-0
Bacopa Monnieri  93164-89-7
Phosphatidylserine 51446-62-9
N-Methyl-D-Aspartic Acid/NMDA 6384-92-5
Memantine HCL 3717-88-2
Duloxetine Hydrochloride 136434-34-9
Semax 80714-61-0
Rivastigmine Tartrate 129101-54-8
Galantamine 357-70-0
Citicoline Sodium 33818-15-4
Nefiracetam 77191-36-7
Picamilon Na+ 62936-56-5
   
Choline Bitartrate 87-67-2
Choline Glycerophosphate/Alpha GPC 28319-77-9
Resveratrol 501-36-0
Melatonine 73-31-4
Noopept 157115-85-0
N, N-Dimethyl-2-Phenylethylamine HCL 10275-21-5
Fasoracetam 110958-19-5
PRL-8-53 HCL 51352-87-5
Unifiram 272786-64-8
Centrophenoxine 3685-84-5
Sunifiram 314728-85-3
Piracetam 7491-74-9
Pramiracetam 68497-62-1
Aniracetam 72432-10-1
Coluracetam/MKC-231 135463-81-9
PRL-8-53 HCL 51352-87-5
Bisibutiamine 3286-46-2
4-Aminobutyric acid/GABA  1959/12/1
Pterostilbene 537-42-8
Ubidecarenone/Coenzyme Q10/Coq10 303-98-0
Vinpocetine 42971-09-5
Oxiracetam 62613-82-5
Idebenone 58186-27-9
9-Fluorenol/Hydrafinil 1689-64-1
DMAE 5988-51-2


Hot Selling Pharmaceutical Raw Material Azelastine Hydrochloride CAS 79307-93-0


If you want to know more about our products,please search:

 
http://www.slsteroid.com



Hot Selling Pharmaceutical Raw Material Azelastine Hydrochloride CAS 79307-93-0
  Details

Product Name: Azelastine hydrochloride 
Synonyms: a5610;azeptin;e-0659;w-2979m;AZELASTINE HCL;AZELASTINE HYDROCHLORIDE;4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one hydrochloride;4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride 
CAS: 79307-93-0 
MF: C22H25Cl2N3O 
MW: 418.36
Product Categories: Antihistaminic;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor;Astelin
Melting point  225--229ºC
Storage temp. : Keep in room temperature . 
Stability: Incompatible with strong oxidizing agents. 
Chemical Properties White Crystalline Powder 
Usage Orally active H1-hystamine receptor antagonist. Antihistaminic.



Description

Astelin (azelastine hydrochloride) Nasal Spray, 137 micrograms (mcg), is an antihistamine formulated as a metered-spray solution for intranasal administration. Azelastine hydrochloride occurs as a white, almost odorless, crystalline powder with a bitter taste. It has a molecular weight of 418.37. It is sparingly soluble in water, methanol, and propylene glycol and slightly soluble in ethanol, octanol, and glycerine. It has a melting point of about 225°C and the pH of a saturated solution is between 5.0 and 5.4. Its chemical name is (±)-1-(2H)-phthalazinone,4-[(4chlorophenyl) methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride.

Astelin Nasal Spray contains 0.1% azelastine hydrochloride in an aqueous solution at pH 6.8 ± 0.3. It also contains benzalkonium chloride (125 mcg/mL), edetate disodium, hypromellose, citric acid, dibasic sodium phosphate, sodium chloride, and purified water.

After priming [see DOSAGE AND ADMINISTRATION], each metered spray delivers a 0.137 mL mean volume containing 137 mcg of azelastine hydrochloride (equivalent to 125 mcg of azelastine base). The bottle can deliver 200 metered sprays.



Hot Selling Pharmaceutical Raw Material Azelastine Hydrochloride CAS 79307-93-0


Application

This medication is used to treat itching eyes caused by allergies (allergic conjunctivitis). Azelastine belongs to a class of drugs known as antihistamines. It works by blocking certain natural substances called histamines that are responsible for allergic symptoms.
 
Azelastine nasal spray is indicated for the local treatment of the symptoms of seasonal allergic rhinitis and perennial allergic rhinitis, such as rhinorrhea, sneezing and nasal pruritus in adults and children 5 years of age and older. In some countries, it is also indicated for the treatment of vasomotor rhinitis in adults and children ≥ 12 years old. Azelastine eyes drops are indicated for the local treatment of seasonal and perennial allergic conjunctivitis.Uses for Azelastine HydrochlorideSeasonal Allergic RhinitisSymptomatic treatment of seasonal allergic rhinitis (e.g., hay fever). Intranasal azelastine is at least as effective as oral antihistamines (e.g., cetirizine) or intranasal corticosteroids.May provide improvement of ocular manifestations, possibly secondary to systemic absorption of the drug.Nonallergic RhinitisSymptomatic treatment of nonallergic (vasomotor) rhinitis;Allergic ConjunctivitisSymptomatic relief of ocular itching associated with allergic conjunctivitis.


Dosage

Available as azelastine hydrochloride; dosage expressed in terms of the salt.1
When properly primed, the nasal spray pump delivers approximately 100 metered doses per bottle.Pediatric PatientsSeasonal Allergic RhinitisIntranasalChildren ≥12 years of age: 2 sprays (274 mcg) in each nostril twice daily.

Children 5-11 years of age: 1 spray (137 mcg) in each nostril twice daily.Nonallergic RhinitisIntranasalChildren ≥12 years of age: 2 sprays (274 mcg) in each nostril twice daily.Allergic ConjunctivitisOphthalmicChildren ≥3 years of age: 1 drop of a 0.05% solution in the affected eye(s) twice daily.AdultsSeasonal Allergic RhinitisIntranasal2 sprays (274 mcg) in each nostril twice daily.Nonallergic RhinitisIntranasal2 sprays (274 mcg) in each nostril twice daily.Allergic ConjunctivitisOphthalmic1 drop of a 0.05% solution in the affected eye(s) twice daily.



Side Effect

Azelastine is safe and well tolerated in both adults and children with allergic rhinitis. Bitter taste, headache, nasal burning and somnolence are the most frequently reported adverse events. US prescribing recommendations warn against the concurrent use of alcohol and/or other central nervous system depressants, but to date there have been no studies to assess the effects of azelastine nasal spray on the CNS in humans.

More recent studies have shown similar degrees of somnolence (approx. 2%) compared with placebo treatment. The problem of bitter taste may be reduced by correct application of the nasal spray (i.e. slightly tipping the head forward and not inhaling the medication too deeply), or alternatively using the azelastine/sucralose formulation.



The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.

2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.

3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.

b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.

4) Before selling 
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.


Our advantage

1, High quality with competitive price:
1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)Customs pass rate ≥ 99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

3, We have clients throughout the world.
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.



FAQ
Order Guide
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept bank transfer, Western Union or Paypal or  Moneygram

Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8 :Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.

We specialized in manufacturing high quality and reliable raw material 
which are widely used in the fields of food, health, cosmetics, pharmaceuticals, and Bodybuilding
 
we have formed a technology and management team that cooperate closely with some  overseas Labs  all speak highly of our safe shipping and goods .
please donot hesitate to contact us.



More Hot  Sale  Product: