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Product Name: GDF-8
Synonyms: Myostatin
Purity:95%
Specification:1mg/vial
Appearance:White powder
Certificate:GMP
Storage:Dry Cool Place
Description:
Myostatin (GDF-8) is a member of the transforming TGF-beta superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength.
The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
GDF-8 is a myostatin inhibitor of muscle growth and development process. Myostatin is present in the healing process of muscles and its nature is to inhibit myogenesis (the process of formation of muscular tissue). Scientists have been studying a new method to enhance the repair and regeneration of both muscle and bone in certain injuries through a new recombinant myostatin propeptide.
GDF-8 works through the blocking of active myostatin made by a recombinant, myostatin propeptide has been able to improve muscle and bone regeneration. Myostatin inhibitors improve wound repair in cases of deep penetrant injuries on muscles and bones.
Applications:
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".
Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
Human myostatin consists of two identical subunits, each consisting of 109 amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer.
Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
How does GDF-8 work?
Some studies show that the lack of myostatin gives rise to impressive results in the increase of muscle mass both in humans and in animals. In bones specifically, the lack of myostatin increases its mineral density, resulting in an increase of the calcium levels of the organism. GDF-8 is stored in bones and it is necessary for the correct functionality of the heart, muscles, and nerves as well as for blood clotting.
While using this recombinant myostatin propeptide, it was found that collagen-rich fibrous tissue was plentiful in the injured area of the individual's treated muscle, which has as a result the improvement of the regenerative capacity of the body.
Myostatin deficiency increases the ostegenic potential (formation of bone tissue) of bone marrow. There have been some studies related to the healing properties of stem cells originated in the bone marrow that has an auto regeneration capacity. This benefit can be promoted by blocking Myostatin on humans.
Myostatin inhibitors are used on muscular dystrophy treatment in the attempt to accomplish the muscle regeneration. Myostatin propeptide enhances muscle regeneration, increases myofiber hypertrophy (an increase in size of skeletal muscle through a growth in size of its component cells) and decreases fibrosis (formation of excess fibrous connective tissue, which can obliterate the function of the affected limb) in muscle healing.
Bulk Peptides:
Our Delivery:
 
FAQ:
1)Location & Working Hours
We are an International source locate in China.
I will answer emails from Monday to Saturday, 8:30 am to 18:00 pm (GMT+8)
2)How long does it takes to get back a response from you?
You should receive a response in less than 24 hours.
3)How do I make an order?
When you choosed the products, please email me, and I will quote for you, if you are satisfied with it, then pay for it, the parcle will be sent for you as soon as possible.
4)How to track my order?
 After I ship your order and have the tracking number, you will receive an email notification. All tracking numbers I provide can be tracked at http://www.17track.net/en. Or you can ask me for helping you track it too.
5)How long does the whole process take, from making an order till receiving the package?
The package will be prepared within 1 working day after payment received and be sent out within 72 hours.Â
The delivery time depends on the shipping situation and customs.Â
The shipping time will not more than 15 working days at most.
6)How about  the shipping cost?
The shipping cost is for the whole order. No matter how many different items and quantity in one orders. The shipping cost will be charged only once.
7)Is there a minimum order?
For raw powder: MOQ is 10g
For oil liquid: MOQ is 50ml
For peptide vial: MOQ is 10 vials
8)Reship Policy
To U.S. We reship for free twice if your package gets seized.Â
To other countries we reship for free once if your package gets seized.Â
If you choose not to reship or the resent package failed to go through again, no refund will be made.
9)Payment Ways
We accept Bank Transfer(T/T ), Western Union, Moneygram, Bitcoin.
*** The Bitboin is a little special for us, our Bitcoin account is always changing, once I gave you the account number, please pay for it at once. Â
10)Refund policy
Our company has a 2 reship policy all foreign countries in case of a seizure.
**We are not responsible if you throw away your products because you cannot find them in our disguised package. If you cannot find your products please email me and I will tell you where to find them.
More Peptide:
Â
MGF
/
PEG-MGF
/
CJC-1295Â
863288-34-0Â
CJC-1295Â DAC
/
PT-141(Bremelanotide)
32780-32-8
MT-1(Melanotan)
75921-69-6Â
MT-2
121062-08-6
GHRP-2
158861-67-7
GHRP-6
87616-84-0
Ipamorelin
170851-70-4
Hexarelin
140703-51-1
Sermorelin
86168-78-7
Oxytocin
50-56-6
TB500
77591-33-4
Pentadecapeptide BPC 157
137525-51-0
Fragment 176-191
/
Triptorelin Acetate
57773-63-4
Tesamorelin
218949-48-5
Gonadorelin
71447-49-9
DSIP
62568-57-4
Selank
129954-34-3
1Â LR3
946870-92-4
SNAP-8
868844-74-0
Epitalon
307297-39-8
AOD-9604
221231-10-3
Adipotide
/
ACE-031
/
GDF-8
/
Follistatin 344
/
Follistatin 315
/
DeslorelinÂ
57773-65-6
Nonapeptide-1/Melanostatine-5
/
Thyrotropin/TRH
/
Seractide/Â ACTHÂ (1-39)
/
DermorphinÂ
77614-16-5
Myostatin
/
Product Name: GDF-8
Synonyms: Myostatin
Purity:95%
Specification:1mg/vial
Appearance:White powder
Certificate:GMP
Storage:Dry Cool Place
Description:
Myostatin (GDF-8) is a member of the transforming TGF-beta superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength.
The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
GDF-8 is a myostatin inhibitor of muscle growth and development process. Myostatin is present in the healing process of muscles and its nature is to inhibit myogenesis (the process of formation of muscular tissue). Scientists have been studying a new method to enhance the repair and regeneration of both muscle and bone in certain injuries through a new recombinant myostatin propeptide.
GDF-8 works through the blocking of active myostatin made by a recombinant, myostatin propeptide has been able to improve muscle and bone regeneration. Myostatin inhibitors improve wound repair in cases of deep penetrant injuries on muscles and bones.
Applications:
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".
Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
Human myostatin consists of two identical subunits, each consisting of 109 amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer.
Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
How does GDF-8 work?
Some studies show that the lack of myostatin gives rise to impressive results in the increase of muscle mass both in humans and in animals. In bones specifically, the lack of myostatin increases its mineral density, resulting in an increase of the calcium levels of the organism. GDF-8 is stored in bones and it is necessary for the correct functionality of the heart, muscles, and nerves as well as for blood clotting.
While using this recombinant myostatin propeptide, it was found that collagen-rich fibrous tissue was plentiful in the injured area of the individual's treated muscle, which has as a result the improvement of the regenerative capacity of the body.
Myostatin deficiency increases the ostegenic potential (formation of bone tissue) of bone marrow. There have been some studies related to the healing properties of stem cells originated in the bone marrow that has an auto regeneration capacity. This benefit can be promoted by blocking Myostatin on humans.
Myostatin inhibitors are used on muscular dystrophy treatment in the attempt to accomplish the muscle regeneration. Myostatin propeptide enhances muscle regeneration, increases myofiber hypertrophy (an increase in size of skeletal muscle through a growth in size of its component cells) and decreases fibrosis (formation of excess fibrous connective tissue, which can obliterate the function of the affected limb) in muscle healing.
Bulk Peptides:
Our Delivery:
Â
FAQ:
1)Location & Working Hours
We are an International source locate in China.
I will answer emails from Monday to Saturday, 8:30 am to 18:00 pm (GMT+8)
2)How long does it takes to get back a response from you?
You should receive a response in less than 24 hours.
3)How do I make an order?
When you choosed the products, please email me, and I will quote for you, if you are satisfied with it, then pay for it, the parcle will be sent for you as soon as possible.
4)How to track my order?
 After I ship your order and have the tracking number, you will receive an email notification. All tracking numbers I provide can be tracked at http://www.17track.net/en. Or you can ask me for helping you track it too.
5)How long does the whole process take, from making an order till receiving the package?
The package will be prepared within 1 working day after payment received and be sent out within 72 hours.Â
The delivery time depends on the shipping situation and customs.Â
The shipping time will not more than 15 working days at most.
6)How about  the shipping cost?
The shipping cost is for the whole order. No matter how many different items and quantity in one orders. The shipping cost will be charged only once.
7)Is there a minimum order?
For raw powder: MOQ is 10g
For oil liquid: MOQ is 50ml
For peptide vial: MOQ is 10 vials
8)Reship Policy
To U.S. We reship for free twice if your package gets seized.Â
To other countries we reship for free once if your package gets seized.Â
If you choose not to reship or the resent package failed to go through again, no refund will be made.
9)Payment Ways
We accept Bank Transfer(T/T ), Western Union, Moneygram, Bitcoin.
*** The Bitboin is a little special for us, our Bitcoin account is always changing, once I gave you the account number, please pay for it at once. Â
10)Refund policy
Our company has a 2 reship policy all foreign countries in case of a seizure.
**We are not responsible if you throw away your products because you cannot find them in our disguised package. If you cannot find your products please email me and I will tell you where to find them.
More Peptide:
Â
MGF
/
PEG-MGF
/
CJC-1295Â
863288-34-0Â
CJC-1295Â DAC
/
PT-141(Bremelanotide)
32780-32-8
MT-1(Melanotan)
75921-69-6Â
MT-2
121062-08-6
GHRP-2
158861-67-7
GHRP-6
87616-84-0
Ipamorelin
170851-70-4
Hexarelin
140703-51-1
Sermorelin
86168-78-7
Oxytocin
50-56-6
TB500
77591-33-4
Pentadecapeptide BPC 157
137525-51-0
Fragment 176-191
/
Triptorelin Acetate
57773-63-4
Tesamorelin
218949-48-5
Gonadorelin
71447-49-9
DSIP
62568-57-4
Selank
129954-34-3
1Â LR3
946870-92-4
SNAP-8
868844-74-0
Epitalon
307297-39-8
AOD-9604
221231-10-3
Adipotide
/
ACE-031
/
GDF-8
/
Follistatin 344
/
Follistatin 315
/
DeslorelinÂ
57773-65-6
Nonapeptide-1/Melanostatine-5
/
Thyrotropin/TRH
/
Seractide/Â ACTHÂ (1-39)
/
DermorphinÂ
77614-16-5
Myostatin
/
Gdf-8 1mg/Vial Myostatin Bodybuilding Raw Peptides White Powder for Muscle Building
Model NO.: GDF-8
Appearance: White Powder
Delivery Time: 4-7 Working Days
Shipping Time: Within 12 Hours
Shipping Ways: UPS, TNT, EMS, DHL, FedEx etc
Trademark: Desen Nutrition
Transport Package: Foil Bag
Specification: 1mg/vial
Origin: China
HS Code: 2500681303
Model NO.: GDF-8
Appearance: White Powder
Delivery Time: 4-7 Working Days
Shipping Time: Within 12 Hours
Shipping Ways: UPS, TNT, EMS, DHL, FedEx etc
Trademark: Desen Nutrition
Transport Package: Foil Bag
Specification: 1mg/vial
Origin: China
HS Code: 2500681303
Quick Detail: