(CAS: 649735-63-7) Top Quality Small Molecular API BMS582664
Posted on

Model NO.: 649735-63-7
Product Name: BMS582664
CAS No.: 649735-63-7
Mf: C22h24fn5o4
MW: 369.3696232
Delivery by: DHL, TNT, FedEx, Hkems, UPS, etc
Export Markets: Global
Trademark: NEWBIO
Transport Package: Aluminum Foil Bags
Specification: SGS
Origin: China
HS Code: 0000000000
Model NO.: 649735-63-7
Product Name: BMS582664
CAS No.: 649735-63-7
Mf: C22h24fn5o4
MW: 369.3696232
Delivery by: DHL, TNT, FedEx, Hkems, UPS, etc
Export Markets: Global
Trademark: NEWBIO
Transport Package: Aluminum Foil Bags
Specification: SGS
Origin: China
HS Code: 0000000000
Chemical Information:
 
Product Name
BMS582664
Molecular Formula C22H24FN5O4
Molecular Weight 369.3696232
Storage Store at -20°C
Targets VEGFR2 Flk1 FGFR1 VEGFR1 
IC50 25 nM 89 nM 148 nM 380 nM
Dosage
90 mg/kg
 
Stability
3 years   - 20 ºC powder
6 months  -80 ºC dissolved in a solvent
Solubility Soluble in DMSO > 10 mM
General tips For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.
Shipping Condition
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request


Details:
 
Synonyms:Bms 582664;Bms582664;Brivanib alaninate;L-Alanine, (1R)-2-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-1-methylethyl ester;Unii-U2Y5ofn795;(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester;Brivanib alaninate(BMS-582664);L-Alanine (1R)-2-[[4-[(4-fluoro-2-Methyl-1H-indol-5-yloxy)]-5-Methyl-1H-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]isopropyl ester
   
Description:Brivanib Alaninate (BMS-582664) BMS-540215 is a prodrug, an ATP competitive VEGFR2 inhibitor, IC50 of 25 nM.
 
 
Application:
 
BMS-582664 inhibits VEGF and FGF-stimulated HUVECs proliferation, IC50 of 40 nM, respectively, and 276 nM. [1] BMS-582664 (2 μM) acting on the VEGF and bFGF stimulated SK-HEP1 cells and HepG-2 cells, significantly inhibited VEGFR-2, FGFR-1, ERK1 / 2 and Akt phosphorylation, and BMS-582664 alone in unstimulated cells, then the ERK1 / 2, Akt, VEGFR-2, and the level of phosphorylation of FGFR-1 has no effect. [2] BMS-582664 to inhibit CYP2C19, CYP3A4 (BFC) and CYP3A4 (BzRes), IC50 were 2.4 μM, 0.51 μM and 1.6 μM. BMS-582664 has a high solid state stability (only 0.3% in the desiccant during 12 weeks at 50 ° C degradation), while at pH 6.5 also has considerable liquid stability. [3]
 
 
Notification:This compound is used only for research and not for human trials!


Other Small Molecular API:
 
AZD9291 1421373-65-0
E7080 417716-92-8
Afatinib diMaleate 439081-18-2
XL184 S-MALATE 1140909-48-3
Crizotinib 877399-52-5
Axitinib 319460-85-0
WZ4002 1213269-23-8
Vandetanib 443913-73-3
Sunitinib 557795-19-4
Regorafenib 755037-03-7
Imatinib 152459-95-5
Foretinib 849217-64-7
trametinib 871700-17-3
Tivozanib 475108-18-0
Pelitinib  257933-82-7
Cediranib 288383-20-0
Selumetinib 606143-52-6
Tozasertib 639089-54-6
CapMatinib 1029712-80-8
Amuvatinib 850879-09-3
Lestaurtinib 111358-88-4
Brivanib 649735-46-6



 
1.The parcels will be sent within 24 hours once the order is verified.
2.Packaging is fully in accordance with customer demand.
3.There will be discounts whether you are an old customer or not.

To your satisfiction, here are our advantages

1.High quality and competetive price
1)we can offer coa certificate and official invoice.
2)we are manufacturer with own lab and factory, can provide high quality products with factory price.
3)products purity is test by our quality department strictly before sending, and you can also ask the third testing organization come and inspect, such as (sgs/ cti/ its), only after your confirmation will we send it out to you.

2.Fast and safe delivery
1)products can be sent out in 24 hours after payment.Tracking number available, fixed service person are 7x24h for you to contact.
2) secure and discreet shipment.Various transportation methods for your choice, like dhl/ups/tnt/fedex/sf-express.
3)customs pass and satisfied rate >99%.
4)for hot sale products we have stock in there for transferring.

3 we have clients throughout the world
1) professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) high quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
Chemical Information:
 
Product Name
BMS582664
Molecular Formula C22H24FN5O4
Molecular Weight 369.3696232
Storage Store at -20°C
Targets VEGFR2 Flk1 FGFR1 VEGFR1 
IC50 25 nM 89 nM 148 nM 380 nM
Dosage
90 mg/kg
 
Stability
3 years   - 20 ºC powder
6 months  -80 ºC dissolved in a solvent
Solubility Soluble in DMSO > 10 mM
General tips For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.
Shipping Condition
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request


Details:
 
Synonyms:Bms 582664;Bms582664;Brivanib alaninate;L-Alanine, (1R)-2-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-1-methylethyl ester;Unii-U2Y5ofn795;(1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester;Brivanib alaninate(BMS-582664);L-Alanine (1R)-2-[[4-[(4-fluoro-2-Methyl-1H-indol-5-yloxy)]-5-Methyl-1H-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]isopropyl ester
   
Description:Brivanib Alaninate (BMS-582664) BMS-540215 is a prodrug, an ATP competitive VEGFR2 inhibitor, IC50 of 25 nM.
 
 
Application:
 
BMS-582664 inhibits VEGF and FGF-stimulated HUVECs proliferation, IC50 of 40 nM, respectively, and 276 nM. [1] BMS-582664 (2 μM) acting on the VEGF and bFGF stimulated SK-HEP1 cells and HepG-2 cells, significantly inhibited VEGFR-2, FGFR-1, ERK1 / 2 and Akt phosphorylation, and BMS-582664 alone in unstimulated cells, then the ERK1 / 2, Akt, VEGFR-2, and the level of phosphorylation of FGFR-1 has no effect. [2] BMS-582664 to inhibit CYP2C19, CYP3A4 (BFC) and CYP3A4 (BzRes), IC50 were 2.4 μM, 0.51 μM and 1.6 μM. BMS-582664 has a high solid state stability (only 0.3% in the desiccant during 12 weeks at 50 ° C degradation), while at pH 6.5 also has considerable liquid stability. [3]
 
 
Notification:This compound is used only for research and not for human trials!


Other Small Molecular API:
 
AZD9291 1421373-65-0
E7080 417716-92-8
Afatinib diMaleate 439081-18-2
XL184 S-MALATE 1140909-48-3
Crizotinib 877399-52-5
Axitinib 319460-85-0
WZ4002 1213269-23-8
Vandetanib 443913-73-3
Sunitinib 557795-19-4
Regorafenib 755037-03-7
Imatinib 152459-95-5
Foretinib 849217-64-7
trametinib 871700-17-3
Tivozanib 475108-18-0
Pelitinib  257933-82-7
Cediranib 288383-20-0
Selumetinib 606143-52-6
Tozasertib 639089-54-6
CapMatinib 1029712-80-8
Amuvatinib 850879-09-3
Lestaurtinib 111358-88-4
Brivanib 649735-46-6



 
1.The parcels will be sent within 24 hours once the order is verified.
2.Packaging is fully in accordance with customer demand.
3.There will be discounts whether you are an old customer or not.

To your satisfiction, here are our advantages

1.High quality and competetive price
1)we can offer coa certificate and official invoice.
2)we are manufacturer with own lab and factory, can provide high quality products with factory price.
3)products purity is test by our quality department strictly before sending, and you can also ask the third testing organization come and inspect, such as (sgs/ cti/ its), only after your confirmation will we send it out to you.

2.Fast and safe delivery
1)products can be sent out in 24 hours after payment.Tracking number available, fixed service person are 7x24h for you to contact.
2) secure and discreet shipment.Various transportation methods for your choice, like dhl/ups/tnt/fedex/sf-express.
3)customs pass and satisfied rate >99%.
4)for hot sale products we have stock in there for transferring.

3 we have clients throughout the world
1) professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) market feedback and goods feedback will be appreciated, meeting customers' requirement is our responsibility.
3) high quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

Dextrose & Maltodextrin

Dextrose Monohydrate,Glucose Powder,Dextrose Mono

Fenghua Jade Motor Co., Ltd. , http://www.bosswholesaler.com