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In vitro cultivation of bovine yellow has been used as a medicine
More than 200 kilograms of in-vitro cultivated bezoar produced by Wuhan Dapeng Pharmaceutical has been purchased by many well-known pharmaceutical manufacturers in China for the production of pharmaceuticals. This indicates that the in vitro cultivation of bezoar has been industrialized and bulk replacement of natural bezoar is used as medicine. Yao Damu, a member of the Chinese Food and Drug Administration Review Committee of the State Food and Drug Administration, believes that because the in vitro cultivation of bezoar is equivalent to high-quality natural bezoar, and the price is less than 1/3 of that of natural bezoar, the quality of the proprietary Chinese medicine containing bezoar will be guaranteed. At the same time, the prices dropped sharply and they entered the homes of ordinary people. It is reported that the current domestic output of natural bezoar is only 1 ton, while the demand is about 200 tons. 1 kilogram of natural bezoar prices between 16 to 200,000 yuan. In view of this, the national food and drug supervision and administration department has approved artificial bezoar, cultivation of bezoar and in vitro cultivation of bezoar three kinds of bovine substitutes. However, artificial bezoar is a bovine substitute that has been artificially formulated. Its composition, structure, and efficacy are indistinguishable from those of natural bezoar, and the prices vary widely. Cultivation of bezoar is a gallstone that artificially promotes the production of bovine body, similar to artificially cultivated pearls. The quality of cultivated bezoar is exactly the same as that of natural bezoar, but the quality is uneven and difficult to control. In vitro cultivation of bezoar in the industrial environment, the principle of the simulation of bovine gallstones, synthetic bovine substitutes, excellent quality and stability. But before this, no company can produce bovine yellow in vitro. Due to the huge price gap, the problem of the mixture of natural bezoar and bezoar substitutes in the production and use of proprietary Chinese medicines is outstanding. In order to solve this problem, in early 2004, the State Food and Drug Administration issued a regulation requiring the use of a variety of clinical acute illness drugs containing bezoar in prescriptions for national drug standards and new bezoar-containing drugs approved by the State Drug Administration. Niuhuang is cultivated with bezoar and in vitro cultivated bezoar instead of bezoar, but it should not be replaced with artificial bezoar. According to reports, in vitro cultivation of bezoar is a national class of new drugs. At present, the company has built an in vitro cultivation of Niuhuang GMP production base, completed the modern production of in vitro cultivation of bezoar. The expert certification organized by the National Pharmacopoeia Commission pointed out that in vitro cultivation of bezoar and natural bezoar can be equivalently used. Industrial production can fundamentally solve the practical problem of scarcity of natural bezoar.