English name:Chymotrypsin
Alias:Chymotrypsin;Alpha-trypsin;Avazyme;Chymar
Classification:
The respiratory system medicine > expectorant medicine > promotes the dissolving of phlegm
Dosage forms:1mg (800U) was used for the injection of trypsin.5mg (4000U).
Pharmacological action :
The peptide chain of protein macromolecules can be cut off, and it becomes a peptide with a small molecular weight, or in the end of protein molecule peptide chain, so as to separate amino acids.
Some lipid hydrolysis can be hydrolyzed.
By this effect, the hydrolysis of fibrous protein and mucin in sputum can be hydrolyzed into polypeptide or amino acid, so that the viscous sputum liquefaction is easy to cough, which is effective for purulent or non-purulent phlegm.
In addition, the trypsin can relax the ligaments and the protein structure of some tissues in the eye.
The function of trypsin and chemotherapeutic drugs to the lesion of the lesion was also promoted.
The pharmacokinetics of glucinase .
Both trypsin and trypsin are strong proteolytic enzymes, and only the hydrolytic sites are different.
The venom of snake venom contains alkaline amino acids, which can be decomposed into non-toxic proteins by the trypsin and trypsin, thereby blocking toxins into the bloodstream and producing toxic effects.
The curative effect of trypsin is better than that of trypsin.
The indications:
1. Used in ophthalmologic surgery to relax the ciliary ligament and reduce the traumatic iris ciliary inflammation;
It can also be used for cataract extraction to make the crystal move easily.
2. Used for wound healing, anti-inflammation and prevention of local edema, hematoma, sprain and swelling, otitis media and rhinitis after surgery.
3. For treatment of chronic bronchitis, bronchiectasis or pulmonary abscess, it can liquefy the purulent and non-purulent sputum, which can be easily coughed up.
4. The treatment of snakebite.
Contraindication:
1.Patients under the age of 1.20, due to vitreous lens membrane ligament is connected firmly, eyeball is lesser, sclera can cause vitreous hernia, stretch or glass fluid traumatic cataract patient is not fixed, because can lead to loss of vitreous humor, it is disabled.
2. Cataract patients with high intraocular pressure or corneal degeneration, as well as those with liquefaction tendencies, are banned.
3. Severe liver disease, renal disease, abnormal coagulation function and the application of anticoagulants are prohibited.
Notes:
1. Allergy test should be done before intravenous trypsin intramuscular injection, and intravenous injection should be prohibited.
2. If it causes allergic reaction, it should be stopped immediately and treated with antihistamines.
3. Trypsin has a strong toxicity to the retina, which can cause crystal damage and do not allow the liquid to penetrate into the vitreous.
4. Trypsin is rapidly inactivated in the blood, so no clotting of the blood can be found at the site of the drug.
5. Trypsin is stable in solid state, but its solution is unstable, and it can lose 50% of the activity at room temperature for 9 days. Therefore, it should be prepared before use.
6. The symptoms of glaucoma caused by the trypsin of trypsin are likely to be alleviated after the postoperative use of beta-blockers (such as thiolol) or oral carbonic anhydrase inhibitors (such as acetazolamide).
7. After the effect of the ultrasonic atomization on the decrease of the curd rate of trypsin, it was appropriate to control the inhalation of trypsin with the ultrasound in 5min.
Adverse reactions :
1. The local administration of ophthalmology generally does not cause systemic adverse reactions, but can cause short-term increased intraocular pressure, cause sore eyes, eye pigment meningitis and corneal edema, this kind of glaucoma symptoms sustainable fade after 1 week, can also cause corneal linear opacity, vitreous hernia, iris pigment loss, uveitis, and cracking or delayed healing wound, etc.
2. Blood system: pancreatopinase can cause coagulant dysfunction.
3. Other:(1) intramuscular injection may cause anaphylactic shock.
(2) trypsin can cause histamine release, causing pain and swelling in local injection sites.
Usage :
1. Usually 1 4000U, before use, the trypsin is dissolved in 5ml of sodium chloride injection.
2. The eye drug delivery: used for eye lens zonular ligament as enzymatic decomposition, dissolve in sodium chloride injection chymotrypsin, match into 1:5000 solution, from the pupil into the back room, after 2 ~ 3 min, after the crystal floating, flush with sodium chloride injection, can remove the lens.
3. Spray inhalation: for liquid sputum, it can be made into 0.05% solution atomization.
4. Local injection:
 (1) in the treatment of soft tissue inflammation or trauma, it can be used to inject a local injection of the liquid in 1ml of the hydrochloride solution of 1ml with the pancreatic coagulinase 800U (1mg).
(2) the snakebite, chymotrypsin 10 ~ 20 mg, each with 4 ml diluted with water injection, snake tooth mark centered around for injection, and in the center of the wound area 2 injection, to 3 cm above the swelling a loop closed 1 ~ 2 layer, according to the different parts of each needle 0.3 ~ 0.7 ml, at least 10 needle, needle up to 26.
5. External use:
(1) common acne, the partial smear of trypsin, 2 times a day.
(2) chronic skin ulcer, pancreatic coagulant protease (400 mu g/ml) aqueous solution, wet application surface, 1 ~ 2h each time.
Â
Drug name:
English name:Chymotrypsin
Alias:Chymotrypsin;Alpha-trypsin;Avazyme;Chymar
Classification:
The respiratory system medicine > expectorant medicine > promotes the dissolving of phlegm
Dosage forms:1mg (800U) was used for the injection of trypsin.5mg (4000U).
Pharmacological action :
The peptide chain of protein macromolecules can be cut off, and it becomes a peptide with a small molecular weight, or in the end of protein molecule peptide chain, so as to separate amino acids.
Some lipid hydrolysis can be hydrolyzed.
By this effect, the hydrolysis of fibrous protein and mucin in sputum can be hydrolyzed into polypeptide or amino acid, so that the viscous sputum liquefaction is easy to cough, which is effective for purulent or non-purulent phlegm.
In addition, the trypsin can relax the ligaments and the protein structure of some tissues in the eye.
The function of trypsin and chemotherapeutic drugs to the lesion of the lesion was also promoted.
The pharmacokinetics of glucinase .
Both trypsin and trypsin are strong proteolytic enzymes, and only the hydrolytic sites are different.
The venom of snake venom contains alkaline amino acids, which can be decomposed into non-toxic proteins by the trypsin and trypsin, thereby blocking toxins into the bloodstream and producing toxic effects.
The curative effect of trypsin is better than that of trypsin.
The indications:
1. Used in ophthalmologic surgery to relax the ciliary ligament and reduce the traumatic iris ciliary inflammation;
It can also be used for cataract extraction to make the crystal move easily.
2. Used for wound healing, anti-inflammation and prevention of local edema, hematoma, sprain and swelling, otitis media and rhinitis after surgery.
3. For treatment of chronic bronchitis, bronchiectasis or pulmonary abscess, it can liquefy the purulent and non-purulent sputum, which can be easily coughed up.
4. The treatment of snakebite.
Contraindication:
1.Patients under the age of 1.20, due to vitreous lens membrane ligament is connected firmly, eyeball is lesser, sclera can cause vitreous hernia, stretch or glass fluid traumatic cataract patient is not fixed, because can lead to loss of vitreous humor, it is disabled.
2. Cataract patients with high intraocular pressure or corneal degeneration, as well as those with liquefaction tendencies, are banned.
3. Severe liver disease, renal disease, abnormal coagulation function and the application of anticoagulants are prohibited.
Notes:
1. Allergy test should be done before intravenous trypsin intramuscular injection, and intravenous injection should be prohibited.
2. If it causes allergic reaction, it should be stopped immediately and treated with antihistamines.
3. Trypsin has a strong toxicity to the retina, which can cause crystal damage and do not allow the liquid to penetrate into the vitreous.
4. Trypsin is rapidly inactivated in the blood, so no clotting of the blood can be found at the site of the drug.
5. Trypsin is stable in solid state, but its solution is unstable, and it can lose 50% of the activity at room temperature for 9 days. Therefore, it should be prepared before use.
6. The symptoms of glaucoma caused by the trypsin of trypsin are likely to be alleviated after the postoperative use of beta-blockers (such as thiolol) or oral carbonic anhydrase inhibitors (such as acetazolamide).
7. After the effect of the ultrasonic atomization on the decrease of the curd rate of trypsin, it was appropriate to control the inhalation of trypsin with the ultrasound in 5min.
Adverse reactions :
1. The local administration of ophthalmology generally does not cause systemic adverse reactions, but can cause short-term increased intraocular pressure, cause sore eyes, eye pigment meningitis and corneal edema, this kind of glaucoma symptoms sustainable fade after 1 week, can also cause corneal linear opacity, vitreous hernia, iris pigment loss, uveitis, and cracking or delayed healing wound, etc.
2. Blood system: pancreatopinase can cause coagulant dysfunction.
3. Other:(1) intramuscular injection may cause anaphylactic shock.
(2) trypsin can cause histamine release, causing pain and swelling in local injection sites.
Usage :
1. Usually 1 4000U, before use, the trypsin is dissolved in 5ml of sodium chloride injection.
2. The eye drug delivery: used for eye lens zonular ligament as enzymatic decomposition, dissolve in sodium chloride injection chymotrypsin, match into 1:5000 solution, from the pupil into the back room, after 2 ~ 3 min, after the crystal floating, flush with sodium chloride injection, can remove the lens.
3. Spray inhalation: for liquid sputum, it can be made into 0.05% solution atomization.
4. Local injection:
 (1) in the treatment of soft tissue inflammation or trauma, it can be used to inject a local injection of the liquid in 1ml of the hydrochloride solution of 1ml with the pancreatic coagulinase 800U (1mg).
(2) the snakebite, chymotrypsin 10 ~ 20 mg, each with 4 ml diluted with water injection, snake tooth mark centered around for injection, and in the center of the wound area 2 injection, to 3 cm above the swelling a loop closed 1 ~ 2 layer, according to the different parts of each needle 0.3 ~ 0.7 ml, at least 10 needle, needle up to 26.
5. External use:
(1) common acne, the partial smear of trypsin, 2 times a day.
(2) chronic skin ulcer, pancreatic coagulant protease (400 mu g/ml) aqueous solution, wet application surface, 1 ~ 2h each time.
Â
Chymotrypsin Lyophilized Powder for Wound Healing
Model NO.: LLP04
Pharmaceutical Technology: Chemical Synthesis
Transport Package: as Your Request
Specification: 800IU
Origin: China
Model NO.: LLP04
Pharmaceutical Technology: Chemical Synthesis
Transport Package: as Your Request
Specification: 800IU
Origin: China
Drug name: